Evaluation of antiproliferative effect of 2, 6, 7-trihydroxy-9-phenyl-3H-xanthene-3-one derivates in vitro (CROSBI ID 664069)
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Podaci o odgovornosti
Harej, Anja ; Klobučar, Marko ; Kraljević Pavelić, Sandra
engleski
Evaluation of antiproliferative effect of 2, 6, 7-trihydroxy-9-phenyl-3H-xanthene-3-one derivates in vitro
Ten biologically active xanthen-3-one derivatives were synthesized. Structures of novel compounds were confirmed by IR, 1H, 13C NMR and mass spectrometry. Majority of tested compounds exerted antiproliferative effects at higher tested concentrations (10–100 µM). Compound 9-(4-chlorophenyl)-2, 6, 7-trihydroxyxanthen-3-one (4) exerted the most potent and selective antiproliferative activity in the micromolar range (0.1–10 µM) on all tested cell lines except on SW620 and is thus suitable for further biological evaluation. The strongest effect of compound 4 on HeLa cells was accompained by induction of mitotic catastrophe and apoptotis. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Electrochemical behaviour of studied compounds was compared to the basic non-substituted compound. Shift of the biological oxidation potential towards lower values was obtained for the substituted compounds pointing to the improvement in the reducing power of the compounds.
xanthen-3-one derivatives, antiproliferative evaluation, antioxidant potency
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Podaci o skupu
12th Central European Oncology Congress, Croatian Society of Oncology’s Best of ASCO® Conference ; 22-25.06.2015
poster
22.06.2015-25.06.2015
Opatija, Hrvatska