engleski

Hemochromatosis gene polymorphisms in multiple sclerosis: a meta-analysis

Introduction: Increasing bodies of evidence support a potential role of iron metabolism in multiple sclerosis (MS). Previous studies examining the association of hemochromatosis (HFE) gene polymorphisms and susceptibility to MS yield inconsistent results. Materials and Methods: We performed a meta-analysis of six studies conducted in populations of Caucasian origin (1871 patients and 2030 controls) using the Comprehensive Meta-analysis 3.0 software. The strength of association between the HFE C282Y and H63D polymorphisms and MS risk was estimated by odds ratios with 95 % confidence intervals. Cochran’s Q-statistic and I-squared tests were applied to quantify heterogeneity among studies. Egger’s test was used to estimate the publication bias. Results: The results demonstrated that the HFE C282Y and H63D polymorphisms had no statistically significant association with an increased MS risk (all P > 0.05) under subsequent genetic comparison models: dominant model (YY+CY vs. CC or DD+HD vs. HH) and allelic contrast (Y vs. C or D vs. H). No evident publication bias or significant heterogeneity among studies was detected. Conclusions: The present study indicates that the HFE C282Y and H63D polymorphisms are not associated with susceptibility to MS in populations of Caucasian origin. Further studies should be conducted to estimate the contribution of HFE polymorphisms to the progression of MS.

hemochromatosis gene ; iron ; multiple sclerosis ; polymorphism

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