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Pregled bibliografske jedinice broj: 945987

Identification of Degradation Products of Praziquantel during the Mechanochemical Activation


Šagud, Ivana; Zanolla, Debora; Perissutti, Beatrice; Passerini, Nadia; Škorić, Irena
Identification of Degradation Products of Praziquantel during the Mechanochemical Activation // Journal of pharmaceutical and biomedical analysis, 159 (2018), -; 291-295 doi:10.1016/j.jpba.2018.07.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Identification of Degradation Products of Praziquantel during the Mechanochemical Activation

Autori
Šagud, Ivana ; Zanolla, Debora ; Perissutti, Beatrice ; Passerini, Nadia ; Škorić, Irena

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 159 (2018); 291-295

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Praziquantel, mechanochemical activation, nuclear magnetic resonance, UPLC, milling

Sažetak
Praziquantel (PZQ) is an inexpensive, low toxicity BCS II class anthelmintic drug used for the treatment of neglected tropical diseases. In earlier papers a mechanochemical activation has been used to induce physical transformations on the drug which would ameliorate its solubility and hence its bioavailability and a systematic study of the effects of varying temperature, frequency and time of milling on drug melting enthalpy and drug recovery was given. In this communication, the focus is on the degradation products that are formed during this mechanical treatment of Praziquantel. In the cogrinding process with povidone and crospovidone several degradation products are formed. Different degradation products are formed, which depend on the type of polymer rather than the process conditions. Two of the most prominent degradation products were identified and their structure proposed on the basis of information obtained from GC-MS, UPLC-MS and 1H NMR techniques.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Citiraj ovu publikaciju

Šagud, Ivana; Zanolla, Debora; Perissutti, Beatrice; Passerini, Nadia; Škorić, Irena
Identification of Degradation Products of Praziquantel during the Mechanochemical Activation // Journal of pharmaceutical and biomedical analysis, 159 (2018), -; 291-295 doi:10.1016/j.jpba.2018.07.002 (međunarodna recenzija, članak, znanstveni)
Šagud, I., Zanolla, D., Perissutti, B., Passerini, N. & Škorić, I. (2018) Identification of Degradation Products of Praziquantel during the Mechanochemical Activation. Journal of pharmaceutical and biomedical analysis, 159 (-), 291-295 doi:10.1016/j.jpba.2018.07.002.
@article{article, year = {2018}, pages = {291-295}, DOI = {10.1016/j.jpba.2018.07.002}, keywords = {praziquantel, mechanochemical activation, nuclear magnetic resonance, UPLC, milling}, journal = {Journal of pharmaceutical and biomedical analysis}, doi = {10.1016/j.jpba.2018.07.002}, volume = {159}, number = {-}, issn = {0731-7085}, title = {Identification of Degradation Products of Praziquantel during the Mechanochemical Activation}, keyword = {praziquantel, mechanochemical activation, nuclear magnetic resonance, UPLC, milling} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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