engleski

Structural investigation of aromatic hydrazones and their complexes by ESI MS/MS

Biological systems have difficulties to differentiate between Fe3+ and Ga3+ ions due to their nearly identical ionic radii, same charge, preferred coordination number and chemical behavior. However, Ga3+ lacks the redox activity of iron (3+/2+ redox chemistry) and is marked as “Trojan Horse” in biological systems [1]. Aroylhydrazones can act as neutral, monoanionic or dianionic ONO tridentate ligands [2]. In this lecture the coordination abilities of aromatic hydrazones derived from nicotinic acid hydrazide and differently substituted 2- hydroxybenzaldehydes towards Fe3+ and Ga3+ will be discussed. Stability constants and the stoichiometry of the corresponding M3+:hydrazone complexes in MeOH/H2O media were determined spectrophotometrically. Mass spectrometry was used for structural characterization of the complexes in solution. The MS/MS spectra and fragmentation pathways of ligands and complexes will be presented. [1] K.D. Mjos, J.F. Cawthray, E. Polishchuk, M.J. Abrams, C. Orvig, Dalton Trans., 45 (2016) 13146–13160. [2] T. Benković, A. Kenđel, J. Parlov-Vuković, D. Kontrec, V. Chiş, S. Miljanić, N. Galić, Spectrochim. Acta. A, 190 (2018) 259–267.

Aromatic hydrazones ; Complexes ; Mass spectrometry

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