engleski

Synthesis of new amidino substituted benzothienofurans and benzodithienophens

In order to develop novel dicationic molecules (pentamidin related) as therapeutic agents[1] for the treatment of opportunistic infections associated with Acquired Immune Deficiency Syndrome (AIDS) we prepared in the multistep synthesis[2, 3] series of new amidino-substituted heterociclyc compounds: 4-ethyl-2, 7-bis-(N-isopropylamidino)-benzo[1, 2-b]thieno-benzo[4, 3-b’ ]furan dihydrochloride 1, 4-ethyl-2, 7-bis-(amidino)-benzo[1, 2-b]thieno-benzo[4, 3-b’ ]furan dihydrochloride 2, 4-ethyl-2, 7-bis-(imidazolylamidino)-benzo[1, 2-b]thieno-benzo[4, 3-b’ ]furan dihydrochloride 3, 2, 7-bis-(N-isopropylamidino)-benzo[1, 2-b:4, 3-b’ ]dithiophene dihydrochloride 4, 2, 7-bis-(amidino)-benzo[1, 2-b:4, 3-b’ ]dithiophene dihydrochloride 5, 2, 7-bis-(imidazolylamidino)-benzo[1, 2-b:4, 3-b’ ]dithiophene dihydrochloride 6. All compounds were caracterizied by 1H and 13C NMR, IR and UV methods, and by elementary analyses.

amidines; intercalators; photochemical synthesis

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