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Pregled bibliografske jedinice broj: 943980

Assigning the absolute configuration of single aliphatic molecules by visual inspection


Ebeling, Daniel; Šekutor, Marina; Stiefermann, Marvin; Tschakert, Jalmar; Dahl, Jeremy E.P.; Carlson, Robert M.K.; Schirmeisen, André; Schreiner, Peter R.
Assigning the absolute configuration of single aliphatic molecules by visual inspection // Nature Communications, 9 (2018), 2420; 1-8 doi:10.1038/s41467-018-04843-z (međunarodna recenzija, članak, znanstveni)


Naslov
Assigning the absolute configuration of single aliphatic molecules by visual inspection

Autori
Ebeling, Daniel ; Šekutor, Marina ; Stiefermann, Marvin ; Tschakert, Jalmar ; Dahl, Jeremy E.P. ; Carlson, Robert M.K. ; Schirmeisen, André ; Schreiner, Peter R.

Izvornik
Nature Communications (2041-1723) 9 (2018), 2420; 1-8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chirality, nanodiamonds, stereochemistry, surface science

Sažetak
Deciphering absolute configuration of a single molecule by direct visual inspection is the next step in compound identification, with far-reaching implications for medicinal chemistry, pharmacology, and natural product synthesis. We demonstrate the feasibility of this approach utilizing low temperature atomic force microscopy (AFM) with a CO-functionalized tip to determine the absolute configuration and orientation of a single, adsorbed [123]tetramantane molecule, the smallest chiral diamondoid. We differentiate between single enantiomers on Cu(111) by direct visual inspection, and furthermore identify molecular dimers and molecular clusters. The experimental results are confirmed by a computational study that allowed quantification of the corresponding intermolecular interactions. The unique toolset of absolute configuration determination combined with AFM tip manipulation opens a route for studying molecular nucleation, including chirality-driven assembly or reaction mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Humboldt Research Fellowship for Postdoctoral Researchers



POVEZANOST RADA


Autor s matičnim brojem:
Marina Šekutor, (312901)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE
  • EconLit


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