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Pregled bibliografske jedinice broj: 943873

Synthesis and complexation properties of novel glycoconjugated calix[4]arenes

Cindro, Nikola; Požar, Josip; Barišić, Dajana; Bregović, Nikola; Pičuljan, Katarina; Tomaš, Renato; Frkanec, Leo; Tomišić, Vladislav
Synthesis and complexation properties of novel glycoconjugated calix[4]arenes // Adriatic NMR
Mali ston, Hrvatska, 2018. (pozvano predavanje, međunarodna recenzija, neobjavljeni rad, znanstveni)

Synthesis and complexation properties of novel glycoconjugated calix[4]arenes

Cindro, Nikola ; Požar, Josip ; Barišić, Dajana ; Bregović, Nikola ; Pičuljan, Katarina ; Tomaš, Renato ; Frkanec, Leo ; Tomišić, Vladislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Adriatic NMR

Mjesto i datum
Mali ston, Hrvatska, 15-17. 6. 2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Calixarene ; complexation ; glycoconjugate

Calixarenes are a class of supramolecular cavitands that can be easily functionalized to give receptors for ionic and neutral species. Structural evolution of these compounds has led to more selective receptors with improved physico-chemical properties. Most of the synthesized calixarene ionic receptors are not sufficiently soluble in water which makes their use quite limited [1]. Water-soluble calixarenes usually own this property to the introduced easily-ionized sulfonic groups. In the scope of this work novel neutral and water- soluble ligands 1–3 (Figure 1) were designed and prepared, and their complexation with alkali-metal cations was investigated. Glucose was embedded in the structure as hydrophilic domain whereas secondary and tertiary amides served as cation-binding sites. The latter motifs were used since the calixarene derivatives comprising such groups were previously proven to form highly stable complexes [2]. Complexation reactions with alkali-metal cations were studied in water, methanol, and formamide thus giving insight into the solvation as well as intra- and intermolecular hydrogen bonds effects. Several techniques were used, such as UV spectrophotometry, isothermal titration calorimetry and NMR spectroscopy.

Izvorni jezik

Znanstvena područja


Projekt / tema
HRZZ-IP-2014-09-7309 - razvoj supramolekulskih receptora kationa i aniona (Vladislav Tomišić, )

Prirodoslovno-matematički fakultet, Zagreb