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Pregled bibliografske jedinice broj: 943341

MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR


Vrček, Valerije; Hok, Lucija; Šakić, Davor; Toma, Mateja; Djaković, Senka; Lapić, Jasmina; Tandarić, Tana
MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR // Adriatic NMR Conference - Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Pičuljan, Katarina (ur.).
Zagreb: Department of Chemistry Faculty of Science, University of Zagreb, Croatia, 2018. str. 37-37 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 943341 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR

Autori
Vrček, Valerije ; Hok, Lucija ; Šakić, Davor ; Toma, Mateja ; Djaković, Senka ; Lapić, Jasmina ; Tandarić, Tana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference - Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Pičuljan, Katarina - Zagreb : Department of Chemistry Faculty of Science, University of Zagreb, Croatia, 2018, 37-37

ISBN
978-953-6076-42-0

Skup
Adriatic NMR Conference

Mjesto i datum
Mali Ston, Hrvatska, 15-17.06.2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
NMR, reaction mechanism, acylation, chlorination

Sažetak
19F and 1H NMR experiments were performed to study the mechanism of selected chemical reactions. In the case of the acylation (ferrocenoylation) of purine and pyrimidine nucleobases, the attention has been focused on the regioselectivity/ regiospecificity of the respective reaction. It has been shown that the reaction centre and the product isomers ratio cannot be determined from the isolated weights alone, but the analysis of ”in situ” NMR spectra is required. In the case of chlorination of the 5-fluorouracil, “in situ” NMR data has been generated under actual reaction condition [2]. The existence of the presumed chlorinated intermediates has been confirmed spectrophotometrically, which is necessary to scheme out the full reaction profile. The two cases demonstrate that the information obtained by “in situ” NMR approach may provide the answers to challenging mechanistic or kinetic studies, or may contribute to the optimization of synthetic routes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-1137 - Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza (OrDeN) (Vrček, Valerije, HRZZ - 2016-06) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Davor Šakić (autor)

Avatar Url Tana Tandarić (autor)

Avatar Url Senka Djaković (autor)

Avatar Url Lucija Hok (autor)

Avatar Url Jasmina Lapić (autor)

Avatar Url Valerije Vrček (autor)

Avatar Url Mateja Toma (autor)

Citiraj ovu publikaciju

Vrček, Valerije; Hok, Lucija; Šakić, Davor; Toma, Mateja; Djaković, Senka; Lapić, Jasmina; Tandarić, Tana
MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR // Adriatic NMR Conference - Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Pičuljan, Katarina (ur.).
Zagreb: Department of Chemistry Faculty of Science, University of Zagreb, Croatia, 2018. str. 37-37 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
Vrček, V., Hok, L., Šakić, D., Toma, M., Djaković, S., Lapić, J. & Tandarić, T. (2018) MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR. U: Bregović, N., Namjesnik, D., Novak, P. & Pičuljan, K. (ur.)Adriatic NMR Conference - Book of abstracts.
@article{article, year = {2018}, pages = {37-37}, keywords = {NMR, reaction mechanism, acylation, chlorination}, isbn = {978-953-6076-42-0}, title = {MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR}, keyword = {NMR, reaction mechanism, acylation, chlorination}, publisher = {Department of Chemistry Faculty of Science, University of Zagreb, Croatia}, publisherplace = {Mali Ston, Hrvatska} }
@article{article, year = {2018}, pages = {37-37}, keywords = {NMR, reaction mechanism, acylation, chlorination}, isbn = {978-953-6076-42-0}, title = {MECHANISTIC INSIGHTS INTO CHEMICAL REACTIONS VIA “IN SITU” NMR}, keyword = {NMR, reaction mechanism, acylation, chlorination}, publisher = {Department of Chemistry Faculty of Science, University of Zagreb, Croatia}, publisherplace = {Mali Ston, Hrvatska} }




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