engleski

Summary

The most devastating consequences of diabetes are associated with its long-term micro- and macrovascular complications and up to 75% of patients with diabetes may experience symptoms of gastrointestinal complications. The pathogenesis of gastrointestinal complications is complex, primarily related to autonomic dysfunction of gastrointestinal tract and also associated with hyperglycemia and duration of diabetes. Over the last decades, following the identification of multiple gut-derived hormones, the gut has been recognized as the largest endocrine organ in our body. Peptides released from various cells act locally via autocrine and paracrine mechanisms, on distant organs via endocrine mechanisms, and as neurotransmitters in the central and peripheral nervous systems. The association between gut microbiota and type 2 diabetes appears to be mediated through the impairment of butyrate secretion and mechanism involving the incretins. Autoimmune diseases have alarming increases worldwide in the past several decades. Autoimmunity develops over time and genetic predisposition, environmental factors like infections and gut dysbiosis play important role in development of autoimmune diseases.

diabetes mellitus ; microvascular complications ; autonomic neuropathy ; gastrointestinal complications ; autoimmune diseases ; incretins

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