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Pregled bibliografske jedinice broj: 942070

Prevalence of tick-borne encephalitis in endemic regions of the Croatian mainland, 2017


Bogdanić, Maja; Avšič-Županc, Tatjana; Babić- Erceg, Andrea; Barbić, Ljubo; Capak, Krunoslav; Jemeršić, Lorena; Jungić, Andreja; Kaić, Bernard; Klobučar, Ana; Kolarić, Branko et al.
Prevalence of tick-borne encephalitis in endemic regions of the Croatian mainland, 2017 // Abstract Book. VI Congress of Macedonian Microbiologists with international participation. FEMS-supported Symposium: "Emerging infections" / Panovski, Nikola (ur.).
Skopje: Datapons, 2018. str. 49-50 (predavanje, međunarodna recenzija, sažetak, ostalo)


Naslov
Prevalence of tick-borne encephalitis in endemic regions of the Croatian mainland, 2017

Autori
Bogdanić, Maja ; Avšič-Županc, Tatjana ; Babić- Erceg, Andrea ; Barbić, Ljubo ; Capak, Krunoslav ; Jemeršić, Lorena ; Jungić, Andreja ; Kaić, Bernard ; Klobučar, Ana ; Kolarić, Branko ; Krčmar, Stjepan ; Madić, Josip ; Miklaušić, Božana ; Ovčar, Dorian ; Pandak, Nenad ; Perić, Ljiljana ; Potočnik-Hunjadi, Tanja ; Prpić, Jelena ; Sabadi, Dario ; Savić, Vladimir ; Stevanović, Vladimir ; Tabain, Irena ; Toplak, Ivan ; Zember, Sanja ; Vilibić- Čavlek, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract Book. VI Congress of Macedonian Microbiologists with international participation. FEMS-supported Symposium: "Emerging infections" / Panovski, Nikola - Skopje : Datapons, 2018, 49-50

Skup
VI Congress of the Macedonian Microbiologists with international participation. FEMS- supported Symposium: "Emerging infections"

Mjesto i datum
Ohrid, Makedonija, 30-05.-02.06.2018.

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Tick-borne encephalitis ; prevalence ; Croatia

Sažetak
INTRODUCTION: Tick-borne encephalitis virus (TBEV) is the most important re-emerging arthropod-borne virus in Europe and Asia. In recent decades, the number of human cases in endemic regions of Europe has increased, endemic areas have spread to higher altitudes and new foci have emerged. The main vectors of TBEV in Europe are ticks Ixodes ricinus. Several studies showed that virus detection in ticks is not a sensitive indicator for risk assessment of human TBEV infection. Various animals have been used as sentinels in TBEV endemic areas, including horses in which asymptomatic TBEV is common with seroprevalence rates of up to 26%. OBJECTIVES: To analyze the prevalence of TBEV in humans and horses in endemic regions of the Croatian mainland. MATERIAL: From January to December 2017, a total of 90 patients with neuroinvasive disease (meningitis/encephalitis), 172 asymptomatic persons and 560 horses were tested for the presence of TBEV RNA and/or TBEV antibodies. METHODS: TBEV IgM/IgG antibodies in human and horse sera were detected using a commercial ELISA. TBEV RNA was detected using a real-time and nested RT-PCR protocol. RESULTS AND CONCLUSION: TBEV infection was confirmed in 11/90 (12.2%) patients with neuroinvasive disease (8 males and 3 females aged 21-68 years) by detection of TBEV IgM and low avidity IgG antibodies. TBEV RNA was detected in one patient. The majority of patients reported risk factors such as frequent visiting forest areas (7/63.6%), rural area of residence (7/63.6%) or frequent tick bites (6/54.5%). Cases showed seasonal distribution (April-November). Four (2.3%) asymptomatic persons were found to be IgG seropositive. In one participant, recent TBEV infection was documented by borderline IgG avidity. TBEV IgG antibodies were detected in 80/560 (14.3%) sentinel horses. Our results highlight the need of multidisciplinary ("One health") surveillance of this re-emerging arboviral zoonosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i reemergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (Tatjana Vilibić-Čavlek, HRZZ)

Ustanove
Hrvatski zavod za javno zdravstvo,
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Opća bolnica Varaždin,
Opća bolnica "Dr. Josip Benčević"