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izvor podataka: crosbi

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia (CROSBI ID 251975)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Šumanović-Glamuzina, Darinka ; Čulo, Filip ; Čulo, Melanie Ivana ; Konjevoda, Paško ; Jerković-Raguž, Marjana A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia // Bosnian journal of basic medical sciences, 17 (2017), 3; 203-210. doi: 10.17305/bjbms.2017.1381

Podaci o odgovornosti

Šumanović-Glamuzina, Darinka ; Čulo, Filip ; Čulo, Melanie Ivana ; Konjevoda, Paško ; Jerković-Raguž, Marjana

engleski

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia

Perinatal hypoxia-ischemia is a specific and important pathological event in neonatal care practice. The data on relationship between the concentrations of cytokines in blood and cerebrospinal fluid (CSF) and perinatal brain injury are scarce. The aim of this study is to evaluate changes in interleukin (IL-1β, IL-6, and IL-18) and tumor necrosis factor alpha (TNF-α) levels in newborns with perinatal hypoxia (PNH). CSF and serum samples of 35 term and near-term (35-40 weeks) newborns with PNH, at the age of 3-96 hours, were analyzed using enzyme-linked immunosorbent assay. Control group consisted of 25 non-asphyxic/non-hypoxic infants of the same age sampled for clinically suspected perinatal meningitis, but proven negative and healthy otherwise. The cytokine values in CSF and serum samples were determined in relation to initial hypoxic-ischemic encephalopathy (HIE) staged according the Sarnat/Sarnat method, and compared with neurological outcome at 12 months of age estimated using Amiel-Tison procedure. The concentrations of IL-6 and TNF-α in serum of PNH patients were significantly higher compared to control group (p = 0.0407 and p = 0.023, respectively). No significant difference between average values of cytokines in relation to the stage of HIE was observed. Significantly higher levels of IL-6 and IL-18 corresponded to a mildly abnormal neurological outcome, while higher levels of IL-6 and TNF-α corresponded to a severely abnormal neurological outcome, at 12 months of age. Elevated serum levels of IL-6 and TNF-α better corresponded with hypoxia/ischemia compared to CSF values, within 96 hours of birth. Also, higher serum levels of IL-6, TNF-α, and IL-18 corresponded better with abnormal neurological outcome at 12 months of age, compared to CSF values.

Neonates ; cytokines ; perinatal hypoxia ; hypoxic-ischemic encephalopathy ; neurological outcome ; IL-1β ; IL-6 ; IL-18 ; TNF-α

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Podaci o izdanju

17 (3)

2017.

203-210

objavljeno

1512-8601

1840-4812

10.17305/bjbms.2017.1381

Povezanost rada

Biologija

Poveznice
Indeksiranost