engleski

Predicting future development of COPD (MARKO study)

Introduction: As COPD is a growing public health problem with increasing morbidity and mortality associated with its progressive nature, early diagnosis and treatment become more and more relevant in management of this disease. Aim and objectives: We aimed to evaluate newly developed health related QoL (HRQoL) questionnaire – MARKO questionnaire (Vrbica, Ž. et al. Croat Med J. 2016 ; 57:425-33.) for the prediction of future development of COPD in a population at risk (active smokers with >20 pack-years). Materials and Methods: These are preliminary data of phase II study of early detection of COPD in at risk cohort recruited by 25 primary care physicians (MARKO study) ; smokers with >20 pack-years, both sexes, aged 40-65 years with no prior diagnosis of COPD. MARKO questionnaire is a self-administered one with 18 items and 3 domains. All subjects were referred to a pulmonologist and after a diagnostic workup (history, physical, lung function, HRQoL, exhaled breath temperature (EBT)) diagnosis and severity of COPD was made according to GOLD. EBT was measured before and after a smoked cigarette. Patients were reassessed for a COPD after 2 years. Results: A subsample of 232 subjects (58.6% male), mean (SD) age 52.1 (7.1) yrs with 36.6 (17.3) pack-years of smoking was reassessed after 2 years. We found out that a change in EBT after a cigarette and the second domain of MARKO questionnaire were significantly predictive for future COPD (AUC 0.96, p<0.001). Conclusion: Our preliminary data shows that MARKO questionnaire combined with EBT could serve as one of the early markers of future COPD in smokers.

COPD, natural history, questionnaire

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