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Pregled bibliografske jedinice broj: 940667

Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds


Brkljačić, Lidija; Jerić, Ivanka
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds // Journal of mass spectrometry, 53 (2018), -; 649-654 doi:10.1002/jms.4201 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 940667 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds

Autori
Brkljačić, Lidija ; Jerić, Ivanka

Izvornik
Journal of mass spectrometry (1076-5174) 53 (2018); 649-654

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
carbonyl compounds, derivatization, MS/MS analysis, hydrazine reagent, hydrazones

Sažetak
Chemical derivatization of carbonyl compounds is a prerequisite for their determination in environmental and biological samples by LC-MS/MS analysis. The main requirements in regard to the good derivatization reagent are fast, selective and quantitative reaction with carbonyl compounds, and efficient fragmentation upon collision-induced dissociation (CID). We have prepared glutamic acid-related hydrazine reagent, and optimized derivatization procedure with benzaldehyde as a model carbonyl compound. The CID spectrum of the obtained hydrazone gave rich fragmentation pattern with numerous abundant fragment ions. Structure-specific fragment ions were selected for the development of sensitive multiple reaction monitoring (MRM) method.

Izvorni jezik
Hrvatski



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( POIROT)

Profili:

Avatar Url Ivanka Jerić (autor)

Citiraj ovu publikaciju

Brkljačić, Lidija; Jerić, Ivanka
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds // Journal of mass spectrometry, 53 (2018), -; 649-654 doi:10.1002/jms.4201 (međunarodna recenzija, članak, znanstveni)
Brkljačić, L. & Jerić, I. (2018) Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds. Journal of mass spectrometry, 53 (-), 649-654 doi:10.1002/jms.4201.
@article{article, year = {2018}, pages = {649-654}, DOI = {10.1002/jms.4201}, keywords = {carbonyl compounds, derivatization, MS/MS analysis, hydrazine reagent, hydrazones}, journal = {Journal of mass spectrometry}, doi = {10.1002/jms.4201}, volume = {53}, number = {-}, issn = {1076-5174}, title = {Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds}, keyword = {carbonyl compounds, derivatization, MS/MS analysis, hydrazine reagent, hydrazones} }
@article{article, year = {2018}, pages = {649-654}, DOI = {10.1002/jms.4201}, keywords = {carbonyl compounds, derivatization, MS/MS analysis, hydrazine reagent, hydrazones}, journal = {Journal of mass spectrometry}, doi = {10.1002/jms.4201}, volume = {53}, number = {-}, issn = {1076-5174}, title = {Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds}, keyword = {carbonyl compounds, derivatization, MS/MS analysis, hydrazine reagent, hydrazones} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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