Napredna pretraga

Pregled bibliografske jedinice broj: 940335

Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens


(Sveučilište u Sarajevu) Ana Maravic, Tomislav Rončević, Lucija Krce, Nada Ilić, Borivoj Galić, Vedrana Čikeš Čulić, Ivana Carev
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens // Drug development and industrial pharmacy, 1 (2019), 1; 1-17 doi:10.1080/03639045.2019.1656736 (međunarodna recenzija, članak, znanstveni)


Naslov
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens

Autori
Ana Maravic, Tomislav Rončević, Lucija Krce, Nada Ilić, Borivoj Galić, Vedrana Čikeš Čulić, Ivana Carev

Kolaboracija
Sveučilište u Sarajevu

Izvornik
Drug development and industrial pharmacy (0363-9045) 1 (2019), 1; 1-17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atomic force microscopy, boroxine, membrane permeability, MRSA, multidrug-resistant pathogens.

Sažetak
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistant opportunistic pathogens associated with skin and wound infections. The antimicrobial testing against eleven bacterial and four fungal species revealed good activity of boroxine against pathogenic filamentous fungi Penicillium funiculosum and Aspergillus niger (MIC50 64 and 128 µg/ml), and a moderate bioactivity against the yeast Candida albicans (MIC50 512 µg/ml). Among the tested multidrug-resistant bacteria, the best antibacterial effect, stable over a 24-h period, was observed against the methicillin-resistant Staphylococcus aureus strain (MRSA) at MIC of 1024 µg/ml. The atomic force microscopy (AFM) used to investigate the morphology of S. aureus cells revealed indentations on its cell envelope after the boroxine exposure. These results show that in addition to the antitumor effect, boroxine exerts wide spectrum antimicrobial activity, thus may help preventing the development of skin and wound-related opportunistic infections.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-6897 - Istraživanje bioaktivnih spojeva iz dalmatinskogbilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje (Mladen Miloš, )

Ustanove
Kemijsko-tehnološki fakultet, Split,
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Profili:

Avatar Url Ana Maravić (autor)

Avatar Url Nada Ilić (autor)

Avatar Url Ivana Carev (autor)

Avatar Url Lucija Krce (autor)

Avatar Url Tomislav Rončević (autor)

Citiraj ovu publikaciju

(Sveučilište u Sarajevu) Ana Maravic, Tomislav Rončević, Lucija Krce, Nada Ilić, Borivoj Galić, Vedrana Čikeš Čulić, Ivana Carev
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens // Drug development and industrial pharmacy, 1 (2019), 1; 1-17 doi:10.1080/03639045.2019.1656736 (međunarodna recenzija, članak, znanstveni)
(Sveučilište u Sarajevu) (Sveučilište u Sarajevu) Ana Maravic, Tomislav Rončević, Lucija Krce, Nada Ilić, Borivoj Galić, Vedrana Čikeš Čulić, Ivana Carev (2019) Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens. Drug development and industrial pharmacy, 1 (1), 1-17 doi:10.1080/03639045.2019.1656736.
@article{article, year = {2019}, pages = {1-17}, DOI = {10.1080/03639045.2019.1656736}, keywords = {atomic force microscopy, boroxine, membrane permeability, MRSA, multidrug-resistant pathogens.}, journal = {Drug development and industrial pharmacy}, doi = {10.1080/03639045.2019.1656736}, volume = {1}, number = {1}, issn = {0363-9045}, title = {Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β- lactamase-producing opportunistic pathogens}, keyword = {atomic force microscopy, boroxine, membrane permeability, MRSA, multidrug-resistant pathogens.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati