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Pregled bibliografske jedinice broj: 939976

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria


Agnew, Thomas; Munnur, Deeksha; Crawford, Kerryanne; Palazzo, Luca; Mikoč, Andreja; Ahel, Ivan
MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria // Frontiers in Microbiology, 9 (2018), 20, 11 doi:10.3389/fmicb.2018.00020 (međunarodna recenzija, članak, znanstveni)


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Naslov
MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria

Autori
Agnew, Thomas ; Munnur, Deeksha ; Crawford, Kerryanne ; Palazzo, Luca ; Mikoč, Andreja ; Ahel, Ivan

Izvornik
Frontiers in Microbiology (1664-302X) 9 (2018); 20, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PARP ; DNA damage repair ; hydrolase ; mitochondria ; ADP-ribosylation ; ADP-ribose ; macrodomain

Sažetak
MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Dysregulation of MacroD1 expression has been shown to be associated with the pathogenesis of several forms of cancer. To date, the physiological functions and sub-cellular localization of MacroD1 are unclear. Previous studies have described nuclear and cytosolic functions of MacroD1. However, in this study we show that endogenous MacroD1 protein is highly enriched within mitochondria. We also show that MacroD1 is highly expressed in human and mouse skeletal muscle. Furthermore, we show that MacroD1 can efficiently remove ADP-ribose from 5′ and 3′-phosphorylated double stranded DNA adducts in vitro. Overall, we have shown that MacroD1 is a mitochondrial protein with promiscuous enzymatic activity that can target the ester bonds of ADP-ribosylated phosphorylated double-stranded DNA ends. These findings have exciting implications for MacroD1 and ADP-ribosylation within the regulation of mitochondrial function and DNA-damage in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4242 - Istraživanje uloge proteinske modifikacije ADP-ribozilacije kod bakterija (ADPRIBAC) (Mikoč, Andreja, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Andreja Mikoč (autor)

Citiraj ovu publikaciju

Agnew, Thomas; Munnur, Deeksha; Crawford, Kerryanne; Palazzo, Luca; Mikoč, Andreja; Ahel, Ivan
MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria // Frontiers in Microbiology, 9 (2018), 20, 11 doi:10.3389/fmicb.2018.00020 (međunarodna recenzija, članak, znanstveni)
Agnew, T., Munnur, D., Crawford, K., Palazzo, L., Mikoč, A. & Ahel, I. (2018) MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria. Frontiers in Microbiology, 9, 20, 11 doi:10.3389/fmicb.2018.00020.
@article{article, year = {2018}, pages = {11}, DOI = {10.3389/fmicb.2018.00020}, chapter = {20}, keywords = {PARP, DNA damage repair, hydrolase, mitochondria, ADP-ribosylation, ADP-ribose, macrodomain}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2018.00020}, volume = {9}, issn = {1664-302X}, title = {MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria}, keyword = {PARP, DNA damage repair, hydrolase, mitochondria, ADP-ribosylation, ADP-ribose, macrodomain}, chapternumber = {20} }
@article{article, year = {2018}, pages = {11}, DOI = {10.3389/fmicb.2018.00020}, chapter = {20}, keywords = {PARP, DNA damage repair, hydrolase, mitochondria, ADP-ribosylation, ADP-ribose, macrodomain}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2018.00020}, volume = {9}, issn = {1664-302X}, title = {MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria}, keyword = {PARP, DNA damage repair, hydrolase, mitochondria, ADP-ribosylation, ADP-ribose, macrodomain}, chapternumber = {20} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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