Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies (CROSBI ID 251533)
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Podaci o odgovornosti
Starčević, Mirta ; Tomičić, M ; Malenica, Maša ; Zah- Mataković, V
engleski
Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies
Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on foetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Although anti-HLA class I antibodies are often detectable in pregnant women, their role in NAIT is considered controversial. We report a case of NAIT where the most sensitive serological analysis and molecular methods could not detect platelet specific antibodies. Only HLA incompatibility and presence of anti-HLA-A24 antibodies in both the mother's and the newborn's serum were proven. CONCLUSION: This case supports the idea that some anti-HLA class I antibodies could cause NAIT.
neonatal alloimune thrombocytopenia
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Podaci o izdanju
99 (4)
2010.
630-632
objavljeno
0803-5253
1651-2227
10.1111/j.1651-2227.2009.01599.x
Povezanost rada
Temeljne medicinske znanosti