engleski

Hyperbaric Oxygen Therapy in Diabetic Wounds - Potential Effects on Vascular Function

Hyperbaric oxygenation is the therapeutic or experimental application of 100% oxygen at a pressure level higher than atmospheric pressure. Treatment with hyperbaric oxygen can be a beneficial adjuvant therapy in various disorders characterized by compromised tissue oxygenation and perfusion. However, the effects of hyperbaric oxygenation cannot be simply explained as a compensation of the oxygen deficit. Hyperbaric oxygenation has a much broader influence and has the ability to alter protein expression, modulate signaling pathways and affect vascular structure and function. In addition to the classical indications for hyperbaric oxygen therapy, such as gas gangrene, carbon monoxide poisoning, decompression sickness etc., hyperbaric oxygenation was also shown to have promising potential in the treatment of chronic diabetic wounds. An increasing number of studies support the benefits of hyperbaric oxygen for enhancing wound healing and decreasing the likelihood of negative events such as amputation. Such clinical and experimental evidence, as well as potential mechanisms of beneficial effects with focus on vascular function will be discussed. Additionally, the lack of complete information and the lack of a sufficient number of well- designed research studies on this topic will also be addressed.

diabetes mellitus, hyperbaric oxygen, wound

nije evidentirano