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Pregled bibliografske jedinice broj: 938370

Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction


Grgurević, Lovorka; Erjavec, Igor; Dumić-Čule, Ivo; Bordukalo- Nikšić, Tatjana; Pauk, Martina; Trkulja, Vladimir; Matičić, Dražen; Pećin, Marko; Lipar, Marija; Perić, Mihaela; Vukičević, Slobodan
Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction // Bone Morphogenetic Proteins: Systems Biology Regulators / Vukičević, Slobodan ; Sampath, T Kuber (ur.).
Švicarska: Springer, 2017. str. 215-228


Naslov
Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction

Autori
Grgurević, Lovorka ; Erjavec, Igor ; Dumić-Čule, Ivo ; Bordukalo- Nikšić, Tatjana ; Pauk, Martina ; Trkulja, Vladimir ; Matičić, Dražen ; Pećin, Marko ; Lipar, Marija ; Perić, Mihaela ; Vukičević, Slobodan

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Bone Morphogenetic Proteins: Systems Biology Regulators

Urednik/ci
Vukičević, Slobodan ; Sampath, T Kuber

Izdavač
Springer

Grad
Švicarska

Godina
2017

Raspon stranica
215-228

ISBN
978-3-319-47505-9

Ključne riječi
BMP6 ; Bone regeneration ; Bone graft substitute ; BMP complications ; Osteogrow ; Autologous blood BMP6 carrier

Sažetak
Complications associated with the clinical use of BMP2 and BMP7 result from the limited understanding of their molecular mechanisms in bone remodeling. Recently, a novel BMP6-based approach has been developed with superior healing results and reduced side effects in preclinical studies. BMP6-containing osteogenic medicinal product called Osteogrow, which is aimed to induce and accelerate bone formation, is currently being tested in clinical studies. It comprises of a biologically compatible autologous carrier made from the patient’s peripheral blood and of rhBMP6 as an active ingredient. Such formulation circumvents the use of animalderived materials, significantly limits inflammatory processes common in commercial bone devices, and renders the carrier flexible and injectable ensuring the ease of use. The ongoing clinical trial results will provide a more detailed insight into the safety, tolerability, pharmacokinetics, and bone healing effects in humans and hopefully provide novel and valuable therapeutic options in the field of bone regeneration.

Izvorni jezik
Engleski

Citiraj ovu publikaciju

Grgurević, Lovorka; Erjavec, Igor; Dumić-Čule, Ivo; Bordukalo- Nikšić, Tatjana; Pauk, Martina; Trkulja, Vladimir; Matičić, Dražen; Pećin, Marko; Lipar, Marija; Perić, Mihaela; Vukičević, Slobodan
Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction // Bone Morphogenetic Proteins: Systems Biology Regulators / Vukičević, Slobodan ; Sampath, T Kuber (ur.).
Švicarska: Springer, 2017. str. 215-228
Grgurević, L., Erjavec, I., Dumić-Čule, I., Bordukalo- Nikšić, T., Pauk, M., Trkulja, V., Matičić, D., Pećin, M., Lipar, M., Perić, M. & Vukičević, S. (2017) Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction. U: Vukičević, S. & Sampath, T. (ur.) Bone Morphogenetic Proteins: Systems Biology Regulators. Švicarska, Springer, str. 215-228.
@inbook{inbook, year = {2017}, pages = {215-228}, keywords = {BMP6, Bone regeneration, Bone graft substitute, BMP complications, Osteogrow, Autologous blood BMP6 carrier}, isbn = {978-3-319-47505-9}, title = {Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction}, keyword = {BMP6, Bone regeneration, Bone graft substitute, BMP complications, Osteogrow, Autologous blood BMP6 carrier}, publisher = {Springer}, publisherplace = {\v{S}vicarska} }