engleski

Dyslipidemia in children and adolescents with anorexia nervosa

Objectives and Study: Anorexia nervosa (AN) carries a risk for numerous metabolic complications, some of which can be lifelong, even fatal. Currently available data on causes and incidence of dyslipidemia in pediatric patients with AN are scarce. The aim of this study was to investigate the relation between the degree of malnutrition and endotype of eating disorder to dyslipidemia and circulating estradiol in patients with AN. Method: This hospital-based study is a retrospective analysis of medical documentation of 183 female patients 7 do 21 years old (average 14, 79±2, 47) who were hospitalized in Centre for eating disorders in children and adolescents, Department of Pediatrics, Clinical Hospital Sestre milosrdnice, during a 10 years period (2005 to 2015). Results: At admission average body mass index (BMI) was 11, 30-20, 03 kg/m2 (15, 77±1, 93). The disease lasted for 0, 7-108 months (12, 8±13, 9 months) at the time of diagnosis and the average loss of weight was 21, 72±9, 94 % in comparison to initial weight. Dyslipidemia, defined as total serum cholesterol >5.0 mmol/L was found in one third of AN patients (35.5 %). Worse anthropometric indicators and presence of amenorrhea at the time of diagnosis have proven to be in positive correlation to dysplipidemia (p=0, 018 and p< 0, 001, respectively). Furthermore, statistically significant higher levels of cholesterol were determined in patients who did not use laxatives (p=0, 046) and who did not vomit (p=0, 037) which demonstrates a correlation of dyslipidaemia to the restrictive endotype of AN (Table 1.). No statistically significant correlation was determined between lipid profile and serum levels of gonadotropins or eastradiol. Conclusion: A negative correlation between elevated serum cholesterol and vomiting or usage of laxatives confirms starvation as a significant risk factor for development of hypercholesterolemia in patients with AN. Physical recovery, spontaneous menstrual cycle and normalization of attitudde towards food are important objectives of treating AN, especially in order to avoid dyslipidemia as risk for future cardiovascular complications.

anorexia nervosa ; children ; adolescents ; restrictive endotype ; dyslipidemia ; amenorrhea

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