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Pregled bibliografske jedinice broj: 93776

Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study


Šprem, Marina; Miličić, Duško; Orešković, Slavko; Ljubojević, Nikola; Kalafatić, Držislav
Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study // Croatian Medical Journal, 41 (2000), 4; 423-427 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 93776 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study

Autori
Šprem, Marina ; Miličić, Duško ; Orešković, Slavko ; Ljubojević, Nikola ; Kalafatić, Držislav

Izvornik
Croatian Medical Journal (0353-9504) 41 (2000), 4; 423-427

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
administration; intravesical; bladder; cross-over studies; ketoprofen; placebo effect; urinary incontinence

Sažetak
To evaluate the therapeutic efficacy of intravesically administered ketoprofen in patients with urodynamically verified detrusor instability. METHODS: This double-blind randomized placebo-controlled cross-over study included 30 patients with urodynamically verified detrusor instability. Their mean age was 44+/-3.6 years (range 37-49) and the median of the parity was 2 years (1-3). The mean duration of symptoms was 18.3+/-3.1 months (range 14-23). After a 6-week screening, patients were randomized to receive ketoprofen or placebo once a day for 4 weeks. Out of 30 patients, 16 started with ketoprofen, and 14 received placebo. After a week of washing period, 16 patients received placebo, and 14 received ketoprofen. The solution for intravesical application was 50 mL of saline with 2 mL (100 mg) of ketoprofen warmed to 37 C. The placebo solution contained 2 mL of distilled water instead of ketoprofen. The assessment including micturition diaries, cystometric measurements, and bacteriological analysis of urine specimens was performed at the beginning of the study and after the treatment. RESULTS: The subjective cure rate was 18/30 after ketoprofen. The instability index was lower after ketoprofen than before treatment or after placebo (p<0.001). Maximal cystometric capacity and the urinary bladder volume at which the patients felt urgency to void were larger after ketoprofen than before it (p<0.001) or after placebo (p<0.001). The number of patients with uninhibited bladder contractions decreased significantly after ketoprofen, but not after placebo (p<0.001). No side effects were observed. CONCLUSION: Intravesically administrated ketoprofen is a feasible and effective treatment for detrusor instability.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
108156
108032

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Šprem, Marina; Miličić, Duško; Orešković, Slavko; Ljubojević, Nikola; Kalafatić, Držislav
Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study // Croatian Medical Journal, 41 (2000), 4; 423-427 (međunarodna recenzija, članak, znanstveni)
Šprem, M., Miličić, D., Orešković, S., Ljubojević, N. & Kalafatić, D. (2000) Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study. Croatian Medical Journal, 41 (4), 423-427.
@article{article, year = {2000}, pages = {423-427}, keywords = {administration, intravesical, bladder, cross-over studies, ketoprofen, placebo effect, urinary incontinence}, journal = {Croatian Medical Journal}, volume = {41}, number = {4}, issn = {0353-9504}, title = {Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study}, keyword = {administration, intravesical, bladder, cross-over studies, ketoprofen, placebo effect, urinary incontinence} }
@article{article, year = {2000}, pages = {423-427}, keywords = {administration, intravesical, bladder, cross-over studies, ketoprofen, placebo effect, urinary incontinence}, journal = {Croatian Medical Journal}, volume = {41}, number = {4}, issn = {0353-9504}, title = {Intravesically administered ketoprofen in a treatment of detrusor instability: cross over study}, keyword = {administration, intravesical, bladder, cross-over studies, ketoprofen, placebo effect, urinary incontinence} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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