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ASSESSING INTERFERENCES OF UPCONVERTING NANOPARTICLES WITH IN VITRO TOXICITY ASSAYS (CROSBI ID 661646)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Pem, Barbara ; Ilić, Krunoslav ; Pavičić, Ivan ; Moros, Maria ; Jurado, Manuel Ocaña ; Becerro Nieto, Ana Isabel ; de la Fuente, Jesús Martínez ; Vinković Vrček, Ivana ASSESSING INTERFERENCES OF UPCONVERTING NANOPARTICLES WITH IN VITRO TOXICITY ASSAYS // Book of Abstract of the 2nd Conference and Spring School on Properties, Design and Applications of Upconversion Nanomaterials / Acosta D.H.C ; Carrero S. G. ; Soriano L. F. (ur.). Valencia: EU COST Action CM1403 UPCON, 2018. str. 123-123

Podaci o odgovornosti

Pem, Barbara ; Ilić, Krunoslav ; Pavičić, Ivan ; Moros, Maria ; Jurado, Manuel Ocaña ; Becerro Nieto, Ana Isabel ; de la Fuente, Jesús Martínez ; Vinković Vrček, Ivana

engleski

ASSESSING INTERFERENCES OF UPCONVERTING NANOPARTICLES WITH IN VITRO TOXICITY ASSAYS

MOTIVATION Upconverting nanoparticles (UPNPs) have lately emerged as candidates for bio-imaging and bio-sensing applications, 1 making the evaluation of their biocompatibility and safety an important task. Presently, biomedical evaluation of metallic nanoparticles (NPs) is based on in vitro assays.2 Due to their unique physicochemical properties, such as large surface area and reactivity, NPs are known to interfere with assay components and detection systems.3 RESULTS The aim of this study was to investigate the interferences caused by differently functionalized UPNPs with conventional cytotoxicity tests. We performed a number of common in vitro assays that determine metabolic activity (MTT and MTS reduction) and oxidative stress (DCFH-DA oxidation, total glutathione level) to assess cytotoxicity. The results demonstrated applicability of different in vitro assays for safety evaluation of UPNPs. The extent and type of interference depended on the UPNPs concentration and the type of assay. CONCLUSIONS This study demonstrates the need for appropriate adaptations of experimental design when conducting cytotoxicity studies of UPNPs, and highlights different approaches to more accurately assess nanotoxicity.

upconverting nanoparticles, safety assesment, viability assays

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Podaci o prilogu

123-123.

2018.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstract of the 2nd Conference and Spring School on Properties, Design and Applications of Upconversion Nanomaterials

Acosta D.H.C ; Carrero S. G. ; Soriano L. F.

Valencia: EU COST Action CM1403 UPCON

Podaci o skupu

2nd Conference and Spring School on Properties, Design and Applications of Upconversion Nanomaterials (UPCON 2018)

poster

02.06.2018-02.06.2018

Valencia, Španjolska

Povezanost rada

Biologija, Farmacija, Kemija