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Pregled bibliografske jedinice broj: 937699

Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil


Bingning Xie, Stuparevic Igor, Wery Maxime, Descrimes Marc, Morillon Antonin, Primig Michael
Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil // 27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
Levico Terme, ITALY: WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2015. str. S190-S190 (poster, podatak o recenziji nije dostupan, sažetak, znanstveni)


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Naslov
Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil

Autori
Bingning Xie, Stuparevic Igor, Wery Maxime, Descrimes Marc, Morillon Antonin, Primig Michael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB) / - Levico Terme, ITALY : WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2015, S190-S190

Skup
27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

Mjesto i datum
Fondazione Edmund Mach, Levico Terme, ITALY, 6-12.9.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
5-FU, Rrp6

Sažetak
5-Fluorouracil (5-FU) has been widely used to treat solid tumors. The drug is known to inhibit enzymes involved in DNA replication (TK) and RNA processing/modification (Rrp6/EXOSC10). However, the molecular mechanism of 5-FU's anti-proliferative activity is not fully understood and 5-FU resistance is a serious clinical problem. We hypothesize that (i) long non- coding RNAs regulated by Rrp6/EXOSC10 are important for 5-FU toxicity and that (ii) elevated levels of the enzyme may confer 5-FU resistance in cancer cells. We compared the transcriptomes of a wild type yeast strain treated with 5-FU to an rrp6 deletion mutant and identified transcripts that respond to the drug, the RRP6 deletion or both. Furthermore, we discovered that RRP6 overexpression confers 5-FU resistance during vegetative growth. Our data offer interesting leads for the discovery of novel protein-coding and non-coding RNAs that may be involved in 5-FU toxicity, and they indicate that elevated levels of Rrp6 compromise 5-FU activity. These results are potentially important for improving 5-FU based chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Profili:

Avatar Url Igor Stuparević (autor)


Citiraj ovu publikaciju:

Bingning Xie, Stuparevic Igor, Wery Maxime, Descrimes Marc, Morillon Antonin, Primig Michael
Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil // 27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
Levico Terme, ITALY: WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2015. str. S190-S190 (poster, podatak o recenziji nije dostupan, sažetak, znanstveni)
Bingning Xie, Stuparevic Igor, Wery Maxime, Descrimes Marc, Morillon Antonin, Primig Michael (2015) Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil. U: 27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB).
@article{article, year = {2015}, pages = {S190-S190}, keywords = {5-FU, Rrp6}, title = {Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil}, keyword = {5-FU, Rrp6}, publisher = {WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, publisherplace = {Fondazione Edmund Mach, Levico Terme, ITALY} }
@article{article, year = {2015}, pages = {S190-S190}, keywords = {5-FU, Rrp6}, title = {Toward elucidating exoribonuclease-dependent mechanisms for the toxicity of and resistance against the anti-cancer drug 5-Fluorouracil}, keyword = {5-FU, Rrp6}, publisher = {WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, publisherplace = {Fondazione Edmund Mach, Levico Terme, ITALY} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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