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Associations between apolipoprotein E genotypes and Hg concentrations in cord blood

The aim of present study was to estimate the potential relations between APOE polymorphisms and concentrations of total, methyl and inorganic Hg (tHg, MeHg, iHg) in cord blood (CB) of newborns whose mothers were exposed to Hg through fish consumption. We were focused on impact of APOE polymorphism of mothers and/or their newborns, since it is not clear whose genotypes could have greater impact on placental toxicokinetics. Mothers (n=398) and newborns (n=573) from central Slovenia and coastal Croatia, participants of EU projects PHIME and CROME-LIFE+, were included in the study. We used existed data set of personal (and lifestyle) characteristics, tHg blood concentrations and archived DNA extracts from maternal leukocytes and cord tissues. CB MeHg was additionally measured by CVAFS (Tekran 2700), iHg estimated by subtraction of MeHg from tHg and DNA genotyped for APOE (rs429358 and rs7412) by TaqMan® SNP assay (Applied Biosystems). Statistics: Wilcoxon rank-sum test, multiple linear regression (STATA).

apolipoprotein E, genotypes, Hg concentrations in cord blood

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