engleski

Positive association of apolipoprotein E allel ε4 with plasma selenium in Croatian pregnant females

Introduction: Relation between apolipoprotein E gene (APOE) polymorphisms (allel ε4 carriers versus non carriers) and metal(loid)s (Hg, As, Pb, Cd, Se) in mothers and their newborns exposed to seafood metal(loid)s was investigated. Apo E is a lipid binding glycoprotein involved in lipid and neuronal metabolism, having antioxidative, metal-binding and immunomodulatory/anti-inflammatory effects. Its three isoforms are encoded by alleles ε2, ε3 and ε4, respectively. Allel ε4 is believed to be beneficial early in life and detrimental in age related diseases3. ε4 carriers could be more susceptible to oxidative stress and metal toxicity. Discussion: Superior selenium status found in healthy pregnant females carriyng allel ε4 could be linked to the ‘APOE ε4 beneficial effects early in life’

selenium status, apolipoprotein E, APOE polymorphism, metal(loid)s

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