Naslov
Solid-State Supramolecular Assembly of Salicylic Acid and 2-Pyridone, 3-Hydroxypyridine or 4-Pyridone

Autori
Lukin, Stipe ; Stolar Tomislav ; Tireli, Martina ; Barišić, Dajana ; Di Michiel, Marco ; Užarević, Krunoslav ; Halasz, Ivan

Izvornik
Croatica chemica acta (0011-1643) 90 (2017), 4; 707-710

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cocrystal, mechanochemistry, in situ monitoring, salicylic acid, hydroxypyridine

Sažetak
Mechanochemical milling of equimolar mixtures of salicylic acid with three hydroxy derivatives of pyridine provided three newphases. With 2-hydroxypyridine, which is in fact present as 2-pyridone, a discrete cocrystal supramolecular assembly is formed. 3- hydroxypyridine and salicylic acid formed a salt and an extended network of hydrogen bonds while the product of the reaction of 4- hydroxypyridine (present as 4-pyridone) and salicylic acid remained structurally uncharacterized. All three hydroxypyridines retain the tautomeric form as in their respective pure phases upon cocrystal formation. Where possible, reaction profiles have been extracted from in situ monitoring via Rietveld refinement to show direct product formation which could be well described using the first-order reaction rate law.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA