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Pregled bibliografske jedinice broj: 936284

Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats


(Institute of Meat Hygiene and Technology) Rašić, Dubravka; Mladinić, Marin; Želježić, Davor; Pizent, Alica; Stefanović, Srđan; Milićević, Dragan; Konjevoda, Paško; Peraica, Maja
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats // Toxicon, 146 (2018), 99-105 doi:10.1016/j.toxicon.2018.03.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats

Autori
Rašić, Dubravka ; Mladinić, Marin ; Želježić, Davor ; Pizent, Alica ; Stefanović, Srđan ; Milićević, Dragan ; Konjevoda, Paško ; Peraica, Maja

Kolaboracija
Institute of Meat Hygiene and Technology

Izvornik
Toxicon (0041-0101) 146 (2018); 99-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Citrinin, DNA damage, ochratoxin A, oxidative stress, resveratrol

Sažetak
A multimycotoxin analysis approach in grains results in frequent simultaneous findings of nephrotoxic mycotoxins ochratoxin A (OTA) and citrinin (CTN). The mechanism of CTN and OTA toxicities in biological systems is not fully understood but it is known that oxidative stress is involved. In this study, oxidative damage of DNA, lipids, and the concentration of glutathione (GSH), as well as possible antioxidative effects of resveratrol (RSV) were studied in vivo. Male adult Wistar rats were treated orally with OTA (0.125 and 0.250 mg kg- 1 b.w.), RSV (20 mg kg-1 b.w.) for 21 days, CTN (20 mg kg-1 b.w.) for two days or with their combinations. The hOGG1 modified comet assay revealed kidneys and liver oxidative DNA damage in OTA + CTN treated animals, which was not reversed by RSV. CTN did not reduce glutathione (GSH) or increase malondialdehyde (MDA) concentration in any tissue, while OTA reduced kidneys GSH and increased kidneys and liver MDA. RSV increased GSH concentrations in all tissues and decreased MDA concentration in the liver only. Oxidative stress is involved in the toxicity of OTA and CTN but it seems that it differs significantly in organs. Most of the effects on GSH and MDA in combined toxicity may be attributed to the toxic effects of OTA. RSV was effective in restoring the depleted GSH in all tissues but had no effect on the MDA concentration and DNA damage.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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