engleski

Measurement of Arsenic, Arsenic Species and Other Elements in Urine, Drinking Water and Hair Samples- Screening of the Situation in Eastern Croatia

Chronic exposure to arsenic (As) both in organic but also in inorganic (more toxic) forms, is still a major public health problem worldwide. It is estimated that hundreds of millions of persons are affected with As problem exposure not limited only to developing countries, but developed countries as well, primarily from natural geological sources (ground water, water used for food preparation or crop irrigation and drinking water) or from anthropogenic sources (e.g. industrial activities). In Eastern part of Croatia, naturally occurring inorganic As in ground water can be present in concentrations less than 1 µg/L up to 610 µg/L. Although public actions were taken to provide affected population with safe drinking water (≤10 µg As/L under the EU Drinking Water Directive), progress is gradual and variable and the concentrations are still above the limit. The aim of this study was make a screening of the situation in Eastern Croatia. We have examined As concentrations in drinking water samples and urine As-concentrations and As- species (organic: dimethylarsinic acid-DMA, monomethylarsonic acid-MA ; inorganic ; and the sum of cationic arsenic species) in more than 100 exposed individuals from Eastern Croatia using liquid chromatography coupled to inductively coupled plasma mass spectrometry-ICPMS and correlated the results of As-concentrations and other elements measured in hair samples in order to get a better insight in the amount of arsenic that could stay in the human body from the chronic exposure to arsenic and to make assessment of the toxic effect of such exposure. The study was financially supported by the Grant of Ministry of Science and Education of the Republic of Croatia 05/2016 Possible early noninvasive biomarkers of chronic exposure to arsenic.

ICPMS ; arsenic ; urine ; human health

Hrvatsko-austrijski bilateralni projekt 05/2016 dr Milić i prof Gössler