Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications (CROSBI ID 250724)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Saftić, Dijana ; Ban, Željka ; Matić, Josipa ; Tumir, Lidija-Marija ; Piantanida, Ivo
engleski
Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications
Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class are nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.
DNA, RNA recognition ; aryl-nucleobase conjugate ; fluorescence ; circular dichroism ; bioimaging ; cytotoxicity
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Podaci o izdanju
26 (30)
2019.
5609-5624
objavljeno
0929-8673
1875-533X
10.2174/0929867325666180508090640