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Pregled bibliografske jedinice broj: 935807

Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications


Saftić, Dijana; Ban, Željka; Matić, Josipa; Tumir, Lidija-Marija; Piantanida, Ivo
Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications // Current medicinal chemistry, 26 (2019), 30; 5609-5624 doi:10.2174/0929867325666180508090640 (međunarodna recenzija, članak, znanstveni)


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Naslov
Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications

Autori
Saftić, Dijana ; Ban, Željka ; Matić, Josipa ; Tumir, Lidija-Marija ; Piantanida, Ivo

Izvornik
Current medicinal chemistry (0929-8673) 26 (2019), 30; 5609-5624

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA, RNA recognition ; aryl-nucleobase conjugate ; fluorescence ; circular dichroism ; bioimaging ; cytotoxicity

Sažetak
Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class are nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Saftić, Dijana; Ban, Željka; Matić, Josipa; Tumir, Lidija-Marija; Piantanida, Ivo
Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications // Current medicinal chemistry, 26 (2019), 30; 5609-5624 doi:10.2174/0929867325666180508090640 (međunarodna recenzija, članak, znanstveni)
Saftić, D., Ban, Ž., Matić, J., Tumir, L. & Piantanida, I. (2019) Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications. Current medicinal chemistry, 26 (30), 5609-5624 doi:10.2174/0929867325666180508090640.
@article{article, year = {2019}, pages = {5609-5624}, DOI = {10.2174/0929867325666180508090640}, keywords = {DNA, RNA recognition, aryl-nucleobase conjugate, fluorescence, circular dichroism, bioimaging, cytotoxicity}, journal = {Current medicinal chemistry}, doi = {10.2174/0929867325666180508090640}, volume = {26}, number = {30}, issn = {0929-8673}, title = {Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications}, keyword = {DNA, RNA recognition, aryl-nucleobase conjugate, fluorescence, circular dichroism, bioimaging, cytotoxicity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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