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Pregled bibliografske jedinice broj: 935145

AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears.


Fuštar Preradović, Ljubica; Đanić, Davorin; Kardum-Skelin, Ika; Šarčević, Božena; Đanić Hadžibegović, Ana
AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears. // Southeastern European Medical Journal (SEEMEDJ), 1 (2017), 2; 19-26 (recenziran, članak, znanstveni)


CROSBI ID: 935145 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears.

Autori
Fuštar Preradović, Ljubica ; Đanić, Davorin ; Kardum-Skelin, Ika ; Šarčević, Božena ; Đanić Hadžibegović, Ana

Izvornik
Southeastern European Medical Journal (SEEMEDJ) (2459-9484) 1 (2017), 2; 19-26

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
AgNORs, parathyroid adenoma, parathyroid hyperplasia

Sažetak
Objective. Minimally invasive surgery is the method of choice in the management of hyperparathyroidism caused by parathyroid adenoma, whereas in case of parathyroid hyperplasia radical operative procedure is necessary to prevent recurrence of the disease. The aim of the study was to investigate morphological and cytochemical parameters differentiating parathyroid adenoma from parathyroid hyperplasia in cytologic smears in preoperative work-up of patients with hyperparathyroidism. Methods. Fifty parathyroid cytologic smears, preoperatively obtained by ultrasound-guided aspiration biopsy were analyzed. Fifty parathyroid cell nuclei per smear were analyzed, and the number of nucleolar organizer region (AgNOR) determined using SFORM software (Vamstec, Zagreb). The results obtained were compared with histopathology findings. Results. The values of nuclear size parameters obtained by morphometric measurement revealed cells with larger nuclei and greater nuclear size diversity to be found in parathyroid adenoma, thus enabling differentiation of parathyroid hyperplasia from parathyroid adenoma in many cases. However, due to overlapping of borderline values, the possibility of error was tried to reduce by determining AgNOR count and structure. The results obtained showed that neither AgNOR count, nor AgNOR classification into individual AgNOR, AgNOR clusters and annular AgNOR had any role in differentiating parathyroid hyperplasia and parathyroid adenoma. Conclusion. Study results showed that AgNOR count and structure cannot help in determining more clearly the border between parathyroid adenoma and hyperplasia in cytologic smears.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
KBC "Sestre Milosrdnice",
Opća bolnica "Dr. Josip Benčević",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju

Fuštar Preradović, Ljubica; Đanić, Davorin; Kardum-Skelin, Ika; Šarčević, Božena; Đanić Hadžibegović, Ana
AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears. // Southeastern European Medical Journal (SEEMEDJ), 1 (2017), 2; 19-26 (recenziran, članak, znanstveni)
Fuštar Preradović, L., Đanić, D., Kardum-Skelin, I., Šarčević, B. & Đanić Hadžibegović, A. (2017) AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears.. Southeastern European Medical Journal (SEEMEDJ), 1 (2), 19-26.
@article{article, year = {2017}, pages = {19-26}, keywords = {AgNORs, parathyroid adenoma, parathyroid hyperplasia}, journal = {Southeastern European Medical Journal (SEEMEDJ)}, volume = {1}, number = {2}, issn = {2459-9484}, title = {AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears.}, keyword = {AgNORs, parathyroid adenoma, parathyroid hyperplasia} }
@article{article, year = {2017}, pages = {19-26}, keywords = {AgNORs, parathyroid adenoma, parathyroid hyperplasia}, journal = {Southeastern European Medical Journal (SEEMEDJ)}, volume = {1}, number = {2}, issn = {2459-9484}, title = {AgNOR Counts in Differential Diagnosis of Parathyroid Adenoma and Hyperplasia in Preoperative Cytologic Smears.}, keyword = {AgNORs, parathyroid adenoma, parathyroid hyperplasia} }




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