engleski

The effect of ginkgo formulations on platelet aggregation in rats

Ginkgo biloba is an herbal remedy can be found as an ingredient of many dietary supplements. Ginkgo contains different biologically active compounds that can inhibit platelet aggregation. Prolonged platelet aggregation can have apositive effect on the cardiovascular system in cancer patients undergoing chemotherapy, but in oncological surgery (in particular major abdominal, gynecological, and operations with reconstructions) it can increase risk of bleeding.Consequently in these patients there is a need for perioperative assess of the impact of ginkgo on platelet aggregation. In this study we investigated the eff ect of diff erent supplements on platelet aggregation available on the free market which by declaration are containing ginkgo extract alone or in combination with other plants. The study was conducted on 24 male rats Y59, divided into 4 groups, depending on the herbal food supplements which was used for treatment. Platelet aggregation was determined on Multiplate analyzer, impedance aggregometry. Prolonged platelet aggregation was measured in groups b ginkgo (P=0.025), c vulkan (P=0.004), d GOI (P=0.035) compared to control group when it was used ADP as agonist. Platelet aggregation where it was used collagen as agonist showed no statistically signifi cant diff erence between groups.

ginkgo ; platelet aggregation

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