engleski

Personalized Medicine of Central Nervous Systemi Diseases and Disordes: Looking Toward the Future

Abstract In recent years, great effort has been made to reveal genetic bases and molecular and cellular mechanisms involved in the pathology of various central nervous system diseases and disorders, which represent the greatest disease burden today. Discovering genetic variants crucial for the predisposition to cerebrovascu- lar, neurodegenerative, or psychiatric diseases should allow prediction and preven- tion of these largely incurable diseases. Identification of molecular and cellular mechanisms involved in their pathogenesis should open up new opportunities for the individual, mechanism-based, personalized treatments, which should reduce the morbidity and mortality in the field. However, at this time, personalized approaches in prediction, diagnosis, and treatment of the central nervous system diseases and disorders are still quite far apart and require a major progress in understanding the basic mechanisms involved in cell death, regeneration, and neuronal and glial interactions in healthy and diseased brain and spinal cord.

personalized treatments, neurodegenerative

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