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Pregled bibliografske jedinice broj: 934

Mild autoxidation of low density lipoproteins


Ukrainczyk, Tatjana; Krilov, Dubravka; Herak, Janko Nikola
Mild autoxidation of low density lipoproteins // Pharmaceutica acta Helvetiae, 71 (1996), 51-56 (podatak o recenziji nije dostupan, članak, znanstveni)


CROSBI ID: 934 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mild autoxidation of low density lipoproteins

Autori
Ukrainczyk, Tatjana ; Krilov, Dubravka ; Herak, Janko Nikola

Izvornik
Pharmaceutica acta Helvetiae 71 (1996); 51-56

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Autoxidation of lipids; Electron paramagnetic resonance; Low density lipoproteins; Oxidizability

Sažetak
The autoxidation of low density lipoproteins was investigated in a closed system, with limited amount of oxygen. The concentrations of several components were monitored :oxygen, aldehydic oxidation products and alpha-tocopherol. The concentration of the lipid radicals generated in the process of lipid peroxidation was monitored by EPR spin trapping method. It was observed that the consumption of oxygen starts quickly after the onset of incubation at the physiological temperature. After prolonged incubation, several types of trapped radicals were formed. At the same time, no consumption of alpha-tocopherol and no formation of aldehydic products of oxidation took place, indicating that the oxidation process is rather mild. The dynamics of oxidation processes were simulated by a mathematical method in which the oxidation is initiated by the degradation products of the preexisting lipid peroxides. The best agreement between the theoretical predictions and the experimental results was obtained with the rate constants which are several orders of magnitude smaller than the corresponding rate constants in "neat" lipids. The possible reasons for the behavior observed are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
006110

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Janko Herak (autor)

Avatar Url Dubravka Krilov (autor)


Citiraj ovu publikaciju

Ukrainczyk, Tatjana; Krilov, Dubravka; Herak, Janko Nikola
Mild autoxidation of low density lipoproteins // Pharmaceutica acta Helvetiae, 71 (1996), 51-56 (podatak o recenziji nije dostupan, članak, znanstveni)
Ukrainczyk, T., Krilov, D. & Herak, J. (1996) Mild autoxidation of low density lipoproteins. Pharmaceutica acta Helvetiae, 71, 51-56.
@article{article, year = {1996}, pages = {51-56}, keywords = {Autoxidation of lipids, Electron paramagnetic resonance, Low density lipoproteins, Oxidizability}, journal = {Pharmaceutica acta Helvetiae}, volume = {71}, title = {Mild autoxidation of low density lipoproteins}, keyword = {Autoxidation of lipids, Electron paramagnetic resonance, Low density lipoproteins, Oxidizability} }
@article{article, year = {1996}, pages = {51-56}, keywords = {Autoxidation of lipids, Electron paramagnetic resonance, Low density lipoproteins, Oxidizability}, journal = {Pharmaceutica acta Helvetiae}, volume = {71}, title = {Mild autoxidation of low density lipoproteins}, keyword = {Autoxidation of lipids, Electron paramagnetic resonance, Low density lipoproteins, Oxidizability} }




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