engleski

HEPATITIS B AND C SEROLOGICAL PROFILES OF LIVER/KIDNEY DONORS AND RECIPIENTS: 10- YEARCROATIAN SINGLE CENTRE ANALYSIS

Introduction: Screening for hepatitis B (HBV) and hepatitis C (HCV) viruses is a requirement in organ transplantation. The information acquired influences organ allocation and post- transplant management. The goal of this review was to determine HBV and HCV serological profiles of liver and kidney donors and recipients. Methods: HBV and HCV serologies were retrospectively obtained for adult liver and kidney recipients and their donors between 6/2006 and 6/2016 using a hospital transplant database. Results: In total 1308 serological profiles of organ recipients and their donors were analyzed. There were 452 kidney (65% male, mean age 49.512.5 years.) and 856 liver recipients (72% male, mean age 55.110.4 years).1.5% kidney and 5.4% liver recipients were hepatitis B surface antigen (HBsAg) positive. 34.5% of kidney and 69.7% of liver recipients were non-immune to HBV. The prevalence of successful pre-transplant HBV vaccine immunity was greater in kidney than in liver recipients (36.9% vs 5.5%). 2.2% of kidney and3.4% of liver recipients were only HBcAb positive. HBV vaccine immunity of both organ recipient groups did not change significantly during period of 10 years(p=ns). There were 2.2% kidney and 15.7% liver HCV antibody positive recipients. 1.1% of kidney and 0.2% of liver recipients were both HBsAg and HCV Ab positive. From the total number of kidney grafts, 8.85% were HBcAbpositive and no kidney grafts were HBsAg or anti-HCV positive. From the total number of liver grafts, 7.7% were HBcAb, 0.1% HBsAg and 0.2% HCVAb positive. Conclusion: The prevalence of HBV and HCV HBV co- infection in organ recipients is low, as well as the prevalence of anti-HCV in kidney patients at the time of transplant. HBV immunity in the pre- transplant liver kidney cohort is low and has not changed significantly in the observed period.

HEPATITIS B ; HEPATITIS c ; LIVER TRANSPLANTATION ; KIDNEY TRANSPLANTATION

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