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Pregled bibliografske jedinice broj: 933619

Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data


(The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys) Steckling, Nadine; Gotti, Alberto; Bose-O’Reilly, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; De Vocht, Frank; Garía, Mercè; Grimalt, Joan O.; Heath, Ester; Hiscock, Rosemary et al.
Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data // Environmental research, 164 (2018), 597-624 doi:.org/10.1016/j.envres.2018.02.041 (međunarodna recenzija, članak, znanstveni)


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Naslov
Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Autori
Steckling, Nadine ; Gotti, Alberto ; Bose-O’Reilly, Stephan ; Chapizanis, Dimitris ; Costopoulou, Danae ; De Vocht, Frank ; Garía, Mercè ; Grimalt, Joan O. ; Heath, Ester ; Hiscock, Rosemary ; Jagodic, Marta ; Karakitsios, Spyros P. ; Kedikoglou, Kleopatra ; Kosjek, Tina ; Leondiadis, Leondios ; Maggos, Thomas ; Mazej, Darja ; Polańska, Kinga ; Povey, Andrew ; Rovira, Joaquim ; Schoierer, Julia ; Schuhmacher, Marta ; Špirić, Zdravko ; Stajnko, Anja ; Stierum, Rob ; Snoj Tratnik, Janja ; Vassiliadou, Irene ; Annesi-Maesano, Isabella ; Horvat, Milena ; Sarigiannis, Dimosthenis A.

Kolaboracija
The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys

Izvornik
Environmental research (0013-9351) 164 (2018); 597-624

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human biomonitoring ; Biomarkers of exposure ; Environment-wide association studies ; Reference values ; Exposure limit values ; Biomonitoring equivalents

Sažetak
Abstract Background The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited. Objectives The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS). Methods In a face-to-face group discussion, scope, content, and structure of the HEALS deliverable “Guidelines for appropriate BoE selection for EWAS studies” were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated. Results 64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135 ; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed. Conclusions Data about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline – snapshot in time without any claim to comprehensiveness – to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima

Ustanove:
Medicinski fakultet, Rijeka,
OIKON d.o.o.

Profili:

Avatar Url Zdravko Špirić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

(The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys) Steckling, Nadine; Gotti, Alberto; Bose-O’Reilly, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; De Vocht, Frank; Garía, Mercè; Grimalt, Joan O.; Heath, Ester; Hiscock, Rosemary et al.
Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data // Environmental research, 164 (2018), 597-624 doi:.org/10.1016/j.envres.2018.02.041 (međunarodna recenzija, članak, znanstveni)
(The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys) (The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys) Steckling, N., Gotti, A., Bose-O’Reilly, S., Chapizanis, D., Costopoulou, D., De Vocht, F., Garía, M., Grimalt, J., Heath, E. & Hiscock, R. (2018) Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data. Environmental research, 164, 597-624 doi:.org/10.1016/j.envres.2018.02.041.
@article{article, year = {2018}, pages = {597-624}, DOI = {doi.org/10.1016/j.envres.2018.02.041}, keywords = {Human biomonitoring, Biomarkers of exposure, Environment-wide association studies, Reference values, Exposure limit values, Biomonitoring equivalents}, journal = {Environmental research}, doi = {doi.org/10.1016/j.envres.2018.02.041}, volume = {164}, issn = {0013-9351}, title = {Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data}, keyword = {Human biomonitoring, Biomarkers of exposure, Environment-wide association studies, Reference values, Exposure limit values, Biomonitoring equivalents} }
@article{article, year = {2018}, pages = {597-624}, DOI = {doi.org/10.1016/j.envres.2018.02.041}, keywords = {Human biomonitoring, Biomarkers of exposure, Environment-wide association studies, Reference values, Exposure limit values, Biomonitoring equivalents}, journal = {Environmental research}, doi = {doi.org/10.1016/j.envres.2018.02.041}, volume = {164}, issn = {0013-9351}, title = {Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data}, keyword = {Human biomonitoring, Biomarkers of exposure, Environment-wide association studies, Reference values, Exposure limit values, Biomonitoring equivalents} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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