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Pregled bibliografske jedinice broj: 933076

Autovalidation and automation of the postanalytical phase of routine hematology and coagulation analyses in a university hospital laboratory


Mlinarić, Ana; Miloš, Marija; Coen Herak, Desiree; Fuček, Mirjana; Rimac, Vladimira; Zadro, Renata; Rogić, Dunja
Autovalidation and automation of the postanalytical phase of routine hematology and coagulation analyses in a university hospital laboratory // Clinical chemistry and laboratory medicine, 56 (2018), 3; 454-462 doi:10.1515/cclm-2017-0402 (međunarodna recenzija, članak, znanstveni)


Naslov
Autovalidation and automation of the postanalytical phase of routine hematology and coagulation analyses in a university hospital laboratory

Autori
Mlinarić, Ana ; Miloš, Marija ; Coen Herak, Desiree ; Fuček, Mirjana ; Rimac, Vladimira ; Zadro, Renata ; Rogić, Dunja

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 56 (2018), 3; 454-462

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Autovalidation ; complete blood count ; postanalytical phase ; routine coagulation tests ; turnaround time

Sažetak
Background: The need to satisfy high-throughput demands for laboratory tests continues to be a challenge. Therefore, we aimed to automate postanalytical phase in hematology and coagulation laboratory by autovalidation of complete blood count (CBC) and routine coagulation test results (prothrombin time [PT], international normalized ratio [PT-INR], activated partial thromboplastin time [APTT], fibrinogen, antithrombin activity [AT] and thrombin time [TT]). Work efficacy and turnaround time (TAT) before and after implementation of automated solutions will be compared. Methods: Ordering panels tailored to specific patient populations were implemented. Rerun and reflex testing rules were set in the respective analyzers’ software (Coulter DxH Connectivity 1601, Beckman Coulter, FL, USA ; AutoAssistant, Siemens Healthcare Diagnostics, Germany), and sample status information was transferred into the laboratory information system. To evaluate if the automation improved TAT and efficacy, data from manually verified results in September and October of 2015 were compared with the corresponding period in 2016 when autovalidation was implemented. Results: Autovalidation rates of 63% for CBC and 65% for routine coagulation test results were achieved. At the TAT of 120 min, the percentage of reported results increased substantially for all analyzed tests, being above 90% for CBC, PT, PT-INR and fibrinogen and 89% for APTT. This output was achieved with three laboratory technicians less compared with the period when the postanalytical phase was not automated. Conclusions: Automation allowed optimized laboratory workflow for specific patient populations, thereby ensuring standardized results reporting. Autovalidation of test results proved to be an efficient tool for improvement of laboratory work efficacy and TAT.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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