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The effectiveness of lixisenatide as an add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes: a multi-center observational study


Božek, Tomislav; Bilić-Ćurčić, Ines; Cigrovski Berković, Maja; Gradišer, Marina; Kurir Tićinović, Tina; Klobučar-Majanović, Sanja; Marušić, Srećko
The effectiveness of lixisenatide as an add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes: a multi-center observational study // Diabetology & Metabolic Syndrome, 10 (2018), 16; 1-5 doi:10.1186/s13098-018-0321-x (međunarodna recenzija, članak, znanstveni)


Naslov
The effectiveness of lixisenatide as an add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes: a multi-center observational study

Autori
Božek, Tomislav ; Bilić-Ćurčić, Ines ; Cigrovski Berković, Maja ; Gradišer, Marina ; Kurir Tićinović, Tina ; Klobučar-Majanović, Sanja ; Marušić, Srećko

Izvornik
Diabetology & Metabolic Syndrome (1758-5996) 10 (2018), 16; 1-5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Insulin therapy ; Incretin therapies ; Novel agents ; Obesity

Sažetak
INTRODUCTION: This observational study aimed to assess the effectiveness of lixisenatide as add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes. METHODS: Patients with diabetes type 2, prescribed with lixisenatide and basal insulin were divided in three groups (premixed insulin, basal bolus insulin and basal oral therapy (BOT). Difference in mean change in HbA1c, body mass index, total insulin doses, fasting blood glucose (FPG) and prandial blood glucose (PPG) were assessed after 3-6-months of follow-up. RESULTS: The primary outcomes were assessed in 111 patients. Lixisenatide added to basal insulin, reduced HbA1c and body weight significantly in all three groups of patients (p < 0.001 for all), with the most prominent reduction in the basal bolus group of patients which had the highest baseline HbA1c compared to premix and BOT treatment groups. Regarding a difference in total insulin dose the reduction was statistically significant in the basal bolus (p = 0.006) and premix group (p < 0.001). FPG and PPG were also significantly reduced over time in all three groups (p < 0.001 for all). A composite outcome (reduction of HbA1c below 7% (53 mmol/mol) with any weight loss) was achieved in 27% of total patients included in the study, reduction of HbA1c below 7% was observed in 30% of patients, while 90% of patients experienced weight reduction. CONCLUSION: These results indicate that lixisenatide add on basal insulin treatment (BIT) can improve glycemic control in a population with long- standing type 2 diabetes and previously uncontrolled on other insulin therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
KBC "Sestre Milosrdnice",
KBC Split,
Klinička bolnica "Dubrava",
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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