Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation (CROSBI ID 249899)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Terzić, Senka ; Udiković-Kolić, Nikolina ; Jurina, Tamara ; Krizman-Matasić, Ivona ; Senta, Ivan ; Mihaljević, Ivan ; Lončar, Jovica ; Smital, Tvrtko ; Ahel, Marijan
engleski
Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation
The biotransformation of three prominent macrolide antibiotics (azithromycin, clarithromycin and erythromycin) by an activated sludge culture, which was adapted to high concentrations of azithromycin (10 mg/L) was investigated. The study included determination of removal kinetics of the parent compounds, identification of their major biotransformation products (TPs) and assessment of ecotoxicological effects of biotransformation. The chemical analyses were performed by ultra- performance liquid chromatography/quadrupole-time- of-flight mass spectrometry, which enabled a tentative identification of TPs formed during the experiments. The ecotoxicological evaluation included two end-points, residual antibiotic activity and toxicity to freshwater algae. The enriched activated sludge culture was capable of degrading all studied macrolide compounds with high removal efficiencies (> 99%) of the parent compounds at elevated concentrations (10 mg/L). The elimination of all three macrolide antibiotics was associated with the formation of different TPs, including several novel compounds previously unreported in the literature. Some of the TPs were rather abundant and contributed significantly to the overall mass balance at the end of the biodegradation experiments. Biodegradation of all investigated macrolides was associated with a pronounced reduction of the residual antibiotic activity and algal toxicity, indicating a rather positive ecotoxicological outcome of the biotransformation processes achieved by the enriched sludge culture.
macrolide antibiotics ; biodegradation: biotransformation ; transformation products ; transformation pathway ; ecotoxicological evaluation
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Podaci o izdanju
349
2018.
143-152
objavljeno
0304-3894
1873-3336
10.1016/j.jhazmat.2018.01.055
Povezanost rada
Interdisciplinarne prirodne znanosti, Kemija