Persistent organochlorine pollutants in placentas sampled from women in Croatia and an evaluation of their DNA damaging potential in vitro (CROSBI ID 249889)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Želježić, Davor ; Herceg Romanić, Snježana ; Klinčić, Darija ; Matek Sarić, Marijana ; Grzunov Letinić, Judita
engleski
Persistent organochlorine pollutants in placentas sampled from women in Croatia and an evaluation of their DNA damaging potential in vitro
This study investigated the levels and distribution of 17 polychlorinated biphenyls (PCBs) and organochlorine pesticides (HCB, α-HCH, β-HCH, γ-HCH, p, p′-DDE, p, p′-DDD, and p, p′-DDT) in placenta samples from women living in the coastal area of Croatia. During November 2012 to February 2013, 51 placenta samples were collected from healthy mothers. This study presents the first report about Croatian placenta samples. Each of the analysed compounds were found in all of the samples ; all of the maximum values were < 1 ng g−1 w.w., and the highest median value found for PCB-28 was 11.2 pg g−1 w.w. PCBs and organochlorine pesticide (OCPs) present in placenta samples were tested for their genotoxic potential using the alkaline comet assay. The alkaline comet assay is one of the most reliable methods in assessing the DNA lesions that occurs in direct interaction of a chemical and the genome. The detected levels of PCBs and OCPs in the placenta did not pose a significant risk to the children’s DNA during embryonic and foetal growth following short-term exposure. PCB and OCP concentrations in the placenta samples did not induce any significant primary damage to DNA in terms of DNA strand breaks and changes in the primary chemical structure, which could be detected by the alkaline comet assay.
POPs ; placenta ; DNA ; comet assay
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
74
2018.
284-291
objavljeno
0090-4341
1432-0703
10.1007/s00244-017-0503-9
Povezanost rada
Biologija, Interdisciplinarne prirodne znanosti, Javno zdravstvo i zdravstvena zaštita