engleski

New insights into HEATR1 functions

Human HEAT repeat containing 1 protein (HEATR1) is the structural and functional homolog of yeast U3 small nucleolar RNA-associated protein 10 (UTP 10). Human HEATR1 is a nucleolar protein that plays a prominent positive role in regulation of rRNA synthesis. Depletion of HEATR1 cause disruption of nucleolar structure and activate the ribosomal biogenesis stress pathway – RPL5 / RPL11 dependent stabilization and activation of the tumor suppressor protein p53.

HEATR1 ; ribosome biogenesis ; p53

News and Views to: Turi Z et. al. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11- MDM2- p53 ribosome biogenesis stress checkpoint pathway in human cells. Cell Cycle 2017