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A young researcher’s guide to NME/Nm23/NDP Kinase

Herak Bosnar, Maja; Radić, Martina; Ćetković, Helena
A young researcher’s guide to NME/Nm23/NDP Kinase // Periodicum biologorum, 120 (2018), 1; 3-9 doi:10.18054/pb.v120i1.6229 (međunarodna recenzija, pregledni rad, znanstveni)

A young researcher’s guide to NME/Nm23/NDP Kinase

Herak Bosnar, Maja ; Radić, Martina ; Ćetković, Helena

Periodicum biologorum (0031-5362) 120 (2018), 1; 3-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Nm23 ; NME ; NDPK ; metastasis supressor

Nucleoside diphosphate kinases (NDPKs) catalyze the exchange of the terminal phosphate from trinucleotides to dinucleotides through a high- energy phosphohistidine intermedier. They are encoded by NME genes and have been found, with a few exceptions, in all living beings. Besides their well-known function as key regulators of the cellular nucleotide homeostasis, they have been appointed numerous additional biochemical and biological functions. The discovery of NME1/NDPK A as the first metastasis suppressor opened new avenues in cancer research. Although the precise role of NME genes/proteins in cancer dissemination is not yet revealed, it seems that further intensive research in this field may lead to new advances in cancer diagnosis and prognosis, as well as encourage new therapeutic strategies.

Izvorni jezik

Znanstvena područja
Biologija, Temeljne medicinske znanosti


Projekt / tema
HRZZ-IP-2014-09-6400 - istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (Kristian Vlahoviček, )
HRZZ-IP-2016-06-4021 - Struktura, funkcija i evolucija proteina Nme6/Nm23-H6 (Maja Herak Bosnar, )

Institut "Ruđer Bošković", Zagreb

Časopis indeksira:

  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus