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Pregled bibliografske jedinice broj: 929607

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.


Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. // Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting
Barcelona, Španjolska, 2016. (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)


CROSBI ID: 929607 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.

Autori
Wardell, Christopher P. ; Fujita, Masashi ; Yamada, Toru ; Simbolo, Michele ; Fassan, Matteo ; Karlic, Rosa ; Polak, Paz ; Kim, Jaegil ; Hatanaka, Yutaka ; Maejima, Kazuhiro ; Lawlor, Rita T. ; Nakanishi, Yoshitsugu ; Mitsuhashi, Tomoko ; Fujimoto, Akihiro ; Furuta, Mayuko ; Ruzzenente, Andrea ; Conci, Simone ; Oosawa, Ayako ; Sasaki-Oku, Aya ; Nakano, Kaoru ; Tanaka, Hiroko ; Yamamoto, Yujiro ; Michiaki, Kubo ; Kawakami, Yoshiiku ; Aikata, Hiroshi ; Ueno, Masaki ; Hayami, Shinya ; Gotoh, Kunihito ; Ariizumi, Shun-ichi ; Yamamoto, Masakazu ; Yamaue, Hiroki ; Chayama, Kazuaki ; Miyano, Satoru ; Getz, Gad ; Scarpa, Aldo ; Hirano, Satoshi ; Nakamura, Toru ; Nakagawa, Hidewaki.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting

Mjesto i datum
Barcelona, Španjolska, 07. -08.04.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Biliary tract cancer ; Cell origin ; Cholangiocarcinoma ; Driver gene ; Genome sequencing ; Predisposing mutation

Sažetak
We analyzed genomic features of 412 BTC samples from Japanese and Italian populations. A total of 32 significantly and commonly mutated genes were identified, some of which negatively affected patient prognosis, including a novel deletion of MUC17 at 7q22.1. Cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs. Deleterious germline mutations of cancer-predisposing genes were detected in 11% of patients with BTC. BTCs have distinct genetic features including somatic events and germline predisposition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
INTEGRA-LIFE
grant 315997
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)


Citiraj ovu publikaciju

Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. // Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting
Barcelona, Španjolska, 2016. (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)
Wardell, C., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlic, R., Polak, P., Kim, J., Hatanaka, Y. & Maejima, K. (2016) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.. U: Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting.
@article{article, year = {2016}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, year = {2016}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, publisherplace = {Barcelona, \v{S}panjolska} }




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