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Pregled bibliografske jedinice broj: 929607

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.


Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. // Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting
Barcelona, Španjolska, 2016. (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)


CROSBI ID: 929607 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.

Autori
Wardell, Christopher P. ; Fujita, Masashi ; Yamada, Toru ; Simbolo, Michele ; Fassan, Matteo ; Karlic, Rosa ; Polak, Paz ; Kim, Jaegil ; Hatanaka, Yutaka ; Maejima, Kazuhiro ; Lawlor, Rita T. ; Nakanishi, Yoshitsugu ; Mitsuhashi, Tomoko ; Fujimoto, Akihiro ; Furuta, Mayuko ; Ruzzenente, Andrea ; Conci, Simone ; Oosawa, Ayako ; Sasaki-Oku, Aya ; Nakano, Kaoru ; Tanaka, Hiroko ; Yamamoto, Yujiro ; Michiaki, Kubo ; Kawakami, Yoshiiku ; Aikata, Hiroshi ; Ueno, Masaki ; Hayami, Shinya ; Gotoh, Kunihito ; Ariizumi, Shun-ichi ; Yamamoto, Masakazu ; Yamaue, Hiroki ; Chayama, Kazuaki ; Miyano, Satoru ; Getz, Gad ; Scarpa, Aldo ; Hirano, Satoshi ; Nakamura, Toru ; Nakagawa, Hidewaki.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting

Mjesto i datum
Barcelona, Španjolska, 07. -08.04.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Biliary tract cancer ; Cell origin ; Cholangiocarcinoma ; Driver gene ; Genome sequencing ; Predisposing mutation

Sažetak
We analyzed genomic features of 412 BTC samples from Japanese and Italian populations. A total of 32 significantly and commonly mutated genes were identified, some of which negatively affected patient prognosis, including a novel deletion of MUC17 at 7q22.1. Cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs. Deleterious germline mutations of cancer-predisposing genes were detected in 11% of patients with BTC. BTCs have distinct genetic features including somatic events and germline predisposition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
INTEGRA-LIFE
grant 315997
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)


Citiraj ovu publikaciju:

Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. // Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting
Barcelona, Španjolska, 2016. (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)
Wardell, C., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlic, R., Polak, P., Kim, J., Hatanaka, Y. & Maejima, K. (2016) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.. U: Pancancer Analysis of Whole Genomes (PCAWG) face-to-face meeting.
@article{article, author = {Wardell, Christopher P. and Fujita, Masashi and Yamada, Toru and Simbolo, Michele and Fassan, Matteo and Karlic, Rosa and Polak, Paz and Kim, Jaegil and Hatanaka, Yutaka and Maejima, Kazuhiro and Lawlor, Rita T. and Nakanishi, Yoshitsugu and Mitsuhashi, Tomoko and Fujimoto, Akihiro and Furuta, Mayuko and Ruzzenente, Andrea and Conci, Simone and Oosawa, Ayako and Sasaki-Oku, Aya and Nakano, Kaoru and Tanaka, Hiroko and Yamamoto, Yujiro and Michiaki, Kubo and Kawakami, Yoshiiku and Aikata, Hiroshi and Ueno, Masaki and Hayami, Shinya and Gotoh, Kunihito and Ariizumi, Shun-ichi and Yamamoto, Masakazu and Yamaue, Hiroki and Chayama, Kazuaki and Miyano, Satoru and Getz, Gad and Scarpa, Aldo and Hirano, Satoshi and Nakamura, Toru and Nakagawa, Hidewaki.}, year = {2016}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Wardell, Christopher P. and Fujita, Masashi and Yamada, Toru and Simbolo, Michele and Fassan, Matteo and Karlic, Rosa and Polak, Paz and Kim, Jaegil and Hatanaka, Yutaka and Maejima, Kazuhiro and Lawlor, Rita T. and Nakanishi, Yoshitsugu and Mitsuhashi, Tomoko and Fujimoto, Akihiro and Furuta, Mayuko and Ruzzenente, Andrea and Conci, Simone and Oosawa, Ayako and Sasaki-Oku, Aya and Nakano, Kaoru and Tanaka, Hiroko and Yamamoto, Yujiro and Michiaki, Kubo and Kawakami, Yoshiiku and Aikata, Hiroshi and Ueno, Masaki and Hayami, Shinya and Gotoh, Kunihito and Ariizumi, Shun-ichi and Yamamoto, Masakazu and Yamaue, Hiroki and Chayama, Kazuaki and Miyano, Satoru and Getz, Gad and Scarpa, Aldo and Hirano, Satoshi and Nakamura, Toru and Nakagawa, Hidewaki.}, year = {2016}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, publisherplace = {Barcelona, \v{S}panjolska} }




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