Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 929386

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations


Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlić, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations // Journal of hepatology, 68 (2018), 5; 959-969 doi:10.1016/j.jhep.2018.01.009 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 929386 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Autori
Wardell, Christopher P. ; Fujita, Masashi ; Yamada, Toru ; Simbolo, Michele ; Fassan, Matteo ; Karlić, Rosa ; Polak, Paz ; Kim, Jaegil ; Hatanaka, Yutaka ; Maejima, Kazuhiro ; Lawlor, Rita T. ; Nakanishi, Yoshitsugu ; Mitsuhashi, Tomoko ; Fujimoto, Akihiro ; Furuta, Mayuko ; Ruzzenente, Andrea ; Conci, Simone ; Oosawa, Ayako ; Sasaki-Oku, Aya ; Nakano, Kaoru ; Tanaka, Hiroko ; Yamamoto, Yujiro ; Michiaki, Kubo ; Kawakami, Yoshiiku ; Aikata, Hiroshi ; Ueno, Masaki ; Hayami, Shinya ; Gotoh, Kunihito ; Ariizumi, Shun-ichi ; Yamamoto, Masakazu ; Yamaue, Hiroki ; Chayama, Kazuaki ; Miyano, Satoru ; Getz, Gad ; Scarpa, Aldo ; Hirano, Satoshi ; Nakamura, Toru ; Nakagawa, Hidewaki

Izvornik
Journal of hepatology (0168-8278) 68 (2018), 5; 959-969

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Biliary tract cancer ; Cell origin ; Cholangiocarcinoma ; Driver gene ; Genome sequencing ; Predisposing mutation

Sažetak
We here analyzed genomic features of 412 BTC samples from Japanese and Italian populations. A total of 32 significantly and commonly mutated genes were identified, some of which negatively affected patient prognosis, including a novel deletion of MUC17 at 7q22.1. Cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs. Deleterious germline mutations of cancer-predisposing genes were detected in 11% of patients with BTC. BTCs have distinct genetic features including somatic events and germline predisposition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)

Citiraj ovu publikaciju

Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlić, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations // Journal of hepatology, 68 (2018), 5; 959-969 doi:10.1016/j.jhep.2018.01.009 (međunarodna recenzija, članak, znanstveni)
Wardell, C., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlić, R., Polak, P., Kim, J., Hatanaka, Y. & Maejima, K. (2018) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. Journal of hepatology, 68 (5), 959-969 doi:10.1016/j.jhep.2018.01.009.
@article{article, year = {2018}, pages = {959-969}, DOI = {10.1016/j.jhep.2018.01.009}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, journal = {Journal of hepatology}, doi = {10.1016/j.jhep.2018.01.009}, volume = {68}, number = {5}, issn = {0168-8278}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation} }
@article{article, year = {2018}, pages = {959-969}, DOI = {10.1016/j.jhep.2018.01.009}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, journal = {Journal of hepatology}, doi = {10.1016/j.jhep.2018.01.009}, volume = {68}, number = {5}, issn = {0168-8278}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font