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CMV and natural killer cells: shaping the response to vaccination


Goodier, MR; Jonjić, Stipan; Riley, EM; Juranić Lisnić, Vanda
CMV and natural killer cells: shaping the response to vaccination // European journal of immunology, 48 (2017), 1; 50-65 doi:10.1002/eji.201646762 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
CMV and natural killer cells: shaping the response to vaccination

Autori
Goodier, MR ; Jonjić, Stipan ; Riley, EM ; Juranić Lisnić, Vanda

Izvornik
European journal of immunology (0014-2980) 48 (2017), 1; 50-65

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
CMV ; HCMV ; Immune evasion ; NK cells ; Vaccination

Sažetak
Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can leave a long-lasting imprint on the immune system in general and affect responses toward other pathogens and vaccines. This review aims to provide an overview of NK cell biology and development, the manipulation of NK cells by CMVs and the potential impact of these evasion strategies on responses to vaccination.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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