engleski

Noncovalent interactions of a ferrocene substituted iminodiacetamide

The amide group, an important structural motif of amino acids, and therefore, peptides and proteins, can act both as a donor (N-H) and acceptor (C=O) of hydrogen bonds. Studying the amide bond hydrogen bonding ability, gives insight into the formation of secondary and tertiary protein structures. Iminodiacetamide derivatives are well known ligands for late transition metals that give access to a great variety of stuctural motifs and can be conjugated to different molecules, such as the ferrocenyl group, which due to its stability in aqueous and organic media, found use in many biological applications. In this work, we present the crystal structures of two solvatomorphs of a ferrocene amide conjugate Fc-eda-imda and Fc-eda- imda × CDCl3. The difference between the solid state structures of both solvatomorphs is described in detail, using single crystal and powder X ray diffraction. Also, the difference between the structure in the solid state and in chloroform solution is studied with 1H NMR and IR spectroscopy.

amides ; ferrocene ; hydrogen bonding ; supramolecular chemistry

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