engleski

Pharmacogenetics-the possibility of therapy individualization

There is strong evidence for genetic polymorphism of the enzymes involved in the metabolism of drugs and environmental or occupational carcinogens to play a major role in the occurrence of unwanted effects of medication or in the incidence of exposure related tumors. Differences in the drug metabolizing ability can lead to severe toxicity or treatment failure because of the changed ratio between drug dosage and blood concentration of pharmacologically active substance resulting from the polymorphism of the enzymes included in the drug metabolism...

pharmacogenetics; drug metabolizing enzymes; CYP450

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