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Pregled bibliografske jedinice broj: 927701

Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines


Sović, Irena; Jambon, Samy; Kraljević Pavelić, Sandra; Markova-Car, Elitza; Ilić, Nataša; Depauw, Sabine; David-Cordonnier, Marie-Hélène; Karminski-Zamola, Grace
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines // Bioorganic & medicinal chemistry, 26 (2018), 8; 1950-1960 doi:10.1016/j.bmc.2018.02.045 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines

Autori
Sović, Irena ; Jambon, Samy ; Kraljević Pavelić, Sandra ; Markova-Car, Elitza ; Ilić, Nataša ; Depauw, Sabine ; David-Cordonnier, Marie-Hélène ; Karminski-Zamola, Grace

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 26 (2018), 8; 1950-1960

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Isoindolines ; benzothiazole ; benzimidazole ; antiproliferative activity ; DNA binding ; topoisomerase I/II inhibition

Sažetak
In this paper novel isoindolines substituted with cyano and amidino benzimidazoles and benzothiazoles were synthetized as new potential anti-cancer drugs. The new structures were evaluated for antiproliferative activity, cell cycle changes, cell death, as well as DNA binding and topoisomerase inhibition properties on selected compounds. Results showed that all tested compounds exerted antitumor activity, especially amidinobenzothiazole and amidinobenzimidazole substituted isoindolin-1-ones and benzimidazole substituted 1-iminoisoindoline that showed antiproliferative effect in the submicromolar range. Moreover, the DNA-binding properties of selected compounds were evaluated by biophysical and biochemical approaches including thermal denaturation studies, circular dichroism spectra analyses and topoisomerase I/II inhibition assays and results identified some of them as strong DNA ligands, harboring or not additional topoisomerase II inhibition and able to locate in the nucleus as determined by fluorescence microscopy. In conclusion, we evidenced novel cyano- and amidino-substituted isoindolines coupled with benzimidazoles and benzothiazoles as topoisomerase inhibitors and/or DNA binding compounds with potent antitumor activities.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

Napomena
Rad ima odgovarajući doi.10.1016/j bmc 2018.02.045, pristupaćan je u literaturi prematome spada u kategoriju ; usporedni pregled autora prema zn području... u preprint-e (rubrika 2)



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Citiraj ovu publikaciju

Sović, Irena; Jambon, Samy; Kraljević Pavelić, Sandra; Markova-Car, Elitza; Ilić, Nataša; Depauw, Sabine; David-Cordonnier, Marie-Hélène; Karminski-Zamola, Grace
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines // Bioorganic & medicinal chemistry, 26 (2018), 8; 1950-1960 doi:10.1016/j.bmc.2018.02.045 (međunarodna recenzija, članak, znanstveni)
Sović, I., Jambon, S., Kraljević Pavelić, S., Markova-Car, E., Ilić, N., Depauw, S., David-Cordonnier, M. & Karminski-Zamola, G. (2018) Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines. Bioorganic & medicinal chemistry, 26 (8), 1950-1960 doi:10.1016/j.bmc.2018.02.045.
@article{article, year = {2018}, pages = {1950-1960}, DOI = {10.1016/j.bmc.2018.02.045}, keywords = {isoindolines, benzothiazole, benzimidazole, antiproliferative activity, DNA binding, topoisomerase I/II inhibition}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2018.02.045}, volume = {26}, number = {8}, issn = {0968-0896}, title = {Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines}, keyword = {isoindolines, benzothiazole, benzimidazole, antiproliferative activity, DNA binding, topoisomerase I/II inhibition} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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