Stereoselective diol production by multi-enzyme system (CROSBI ID 659241)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vrsalović Presečki, Ana ; Pintarić, Lela ; Švarc, Anera ; Vasić-Rački, Đurđa
engleski
Stereoselective diol production by multi-enzyme system
Within the field of biocatalysis, multi-enzyme cascade reactions are an important strategy for the production of optically active chemicals. This approach is very promising from an environmental and as well the economical point of view since in this manner higher yields and productivities is accomplished, fewer chemicals are spent, isolation of intermediates is avoided and on industrial scale, waste and production costs are reduced. The synthesis of chiral building blocks is always challenging in the field of organic chemistry, especially the production of molecules with two chiral centers, as the chiral 1, 2-diols. These have wide application as synthons for chemical catalysts, agrochemicals and pharmaceuticals and can be produced by chemical and enzymatic methods. The production of specific form of the stereoisomer of 1, 2-diols by enzymatic approach seems to be more attractive since the synthesis takes place under mild conditions and result with high stereoselectivity. An example of multienzyme catalysis for the production of chiral 1, 2 diol will be presented. By coupling stereoselective carboligation reaction catalyzed by benzoylformate decarboxylase, L- selective reduction of carbonyl group with alcohol dehydrogenase and the coenzyme regeneration by formate dehydrogenase, enantiometrically pure diastereoselective diol was successfully produced from inexpensive substrates.
multi-enzyme cascade reaction, asymmetric reduction, stereoselectivity, alcohol dehydrogenase, benzoylformate decarboxylase
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Podaci o prilogu
S10-S10.
2017.
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objavljeno
10.1016/j.jbiotec.2017.06.034
Podaci o matičnoj publikaciji
Journal of biotechnology
Dundar, Munis
Amsterdam: Elsevier
0168-1656
1873-4863
Podaci o skupu
European Biotechnology Congress 2017
pozvano predavanje
01.01.2017-01.01.2017
Dubrovnik, Hrvatska
Povezanost rada
Kemijsko inženjerstvo, Biotehnologija