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Pregled bibliografske jedinice broj: 926136

Latent Toxoplasma Gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia


Šagud, Marina; Vlatković, Suzana; Švob Štrac, Dubravka; Sviben, Mario, živković, Maja; Vilibić, Maja; Vuksan-Ćusa, Bjanka; Mihaljević-Peleš, Alma, Pivac, Nela
Latent Toxoplasma Gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia // Comprehensive psychiatry, [Epub ahead of print] (2018), [Epub ahead of print]; doi.org/10.1016/j.comppsych.2018.02.002, 6 doi:.org/10.1016/j.comppsych.2018.02.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Latent Toxoplasma Gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia

Autori
Šagud, Marina ; Vlatković, Suzana ; Švob Štrac, Dubravka ; Sviben, Mario, živković, Maja ; Vilibić, Maja ; Vuksan-Ćusa, Bjanka ; Mihaljević-Peleš, Alma, Pivac, Nela

Izvornik
Comprehensive psychiatry (0010-440X) [Epub ahead of print] (2018), [Epub ahead of print]; Doi.org/10.1016/j.comppsych.2018.02.002, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Toxoplasma gondii ; Serum lipids, Schizophrenia

Sažetak
Abstract Background Previous studies suggested a complex association between Toxoplasma Gondii (TG) infection and host lipid metabolism. Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear. Methods In this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia. Results In our sample of schizophrenia patients, with the mean age of 43.90 ± 12.70 years, the rate of TG seropositivity was 52.38% and the prevalence of MetS was 17%. Patients with the TG antibodies had lower serum triglyceride levels and body weight compared to TG seronegative patients, despite having more frequently received antipsychotics (clozapine, olanzapine risperidone and quetiapine), which are well known to induce weight gain and metabolic abnormalities. However, the only significant change in metabolic parameters, observed in TG seropositive patients with schizophrenia, was decreased serum triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio. No associations were observed between TG seropositivity and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose levels, waist circumference, BMI and the rate of MetS. Conclusion This is the first report of the association between TG infection and decreased serum triglyceride to HDL-C ratio in a sample of carefully selected men with chronic schizophrenia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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