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Molecular epidemiology and antimicrobial susceptibility of AmpC- and/or extended- spectrum (ESBL) ß-lactamaseproducing Proteus spp. clinical isolates in Zenica-Doboj Canton, Bosnia and Herzegovina. (CROSBI ID 658960)

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Uzunović, Selma ; Ibrahimagić, Amir ; Bedenić, Branka Molecular epidemiology and antimicrobial susceptibility of AmpC- and/or extended- spectrum (ESBL) ß-lactamaseproducing Proteus spp. clinical isolates in Zenica-Doboj Canton, Bosnia and Herzegovina. // IMED 2016, online abstract librarly. Beč, 2016. str. 22-22

Podaci o odgovornosti

Uzunović, Selma ; Ibrahimagić, Amir ; Bedenić, Branka

engleski

Molecular epidemiology and antimicrobial susceptibility of AmpC- and/or extended- spectrum (ESBL) ß-lactamaseproducing Proteus spp. clinical isolates in Zenica-Doboj Canton, Bosnia and Herzegovina.

Aim To investigate prevalence, antimicrobial susceptibility, molecular characteristics, and genetic relationship of AmpC- and/or extended spectrum beta lactamase (ESBL)- producing Proteus spp. clinical isolates in Zenica-Doboj Canton, Bosnia and Herzegovina. Methods Antibiotic susceptibility was determined by disc diffusion and broth microdilution methods according to CLSI guidelines. Double-disk synergy test was performed in order to screen for ESBLs, and combined disk test with phenylboronic acid to detect AmpC β - lactamases. PCR was used to detect blaESBL/blacarb genes. Genetic relatedness of the strains was determined by pulsed-fieldgel- electrophoresis (PFGE). Results Eleven ESBL- producing isolates were included in the study (six inpatients and five outpatients). Susceptibility rate to amoxicillin-clavulanic acid, imipenem and meropenem was 100%. Resistance rate to cefuroxime was 100%, gentamicine 90.9%, piperacillin/tazobactam 81.8%, cefotaxim, ceftriaxone and ceftazidime 72.7%, cefoxitine and ciprofloxacine 63.6% and to cefepime 45.5%. In five (out of 11) isolates multi-drug resistance (MDR) to cephalosporins, cefamicines, amynocligosides and fluoroquinolones was detected. Besides TEM-1 which was detected in all isolates, CTX-M+OXA-1 β-lactamases were detected in seven (out of 11 ; 63.6%) isolates (five blaCTX-M-1 and two blaCTX-M-15 genes), and CMY-2 β-lactamase in two isolates. PFGE showed no genetic relatedness. Conclusion Because of high prevalence of MDR strains in epidemiologically unrelated patients with AmpC- and/or ESBL producing Proteus spp. infection, further surveillance is needed. Molecular characterization and strain typing, or at least phenotypic test for AmpC/ESBL production is important for appropriate therapy and the detection of sources and modes of spread, which is the main step in order to design targeted infection control strategies.

Proteus mirabilis, antimicrobial susceptibility, extended-spectrum beta-lactamases

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Podaci o prilogu

22-22.

2016.

objavljeno

Podaci o matičnoj publikaciji

IMED 2016, online abstract librarly

Beč:

Podaci o skupu

International Meeting on Emerging Diseases and Surveillance

poster

04.11.2016-07.11.2016

Beč, Austrija

Povezanost rada

Temeljne medicinske znanosti