engleski

Short tandem repeat (STR) variation in eight village populations of the island of Korčula (Croatia)

The aim of this study was to analyse STR variation using the data on nine loci (D3S1358, vWA, FGA, THO1, TPOX, CSF1PO, D5S818, D13S317, D7S820) in the populations from eight villages on the island of Korcula, Croatia, in order to analyse its genetic and population structure. The analysis of STR data in this study indicated appreciable degree of genetic homogeneity among studied village populations on the island, even though a so called "east-west dichotomy" and differentiation between the inhabitants of the most recent settlement and the remaining ones was indicated with respect to the loci CSF1PO and TPOX, respectively. The validity of STR markers in assessing genetic structure of small populations and especially in determining the relationships among geographically closely related but reproductively isolated groups remains to be further evaluated, especially in terms of larger number of studied loci in order to possibly find specific markers useful for resolving genetic patterns of variability at regional levels.

human DNA ; loci mutation ; microsatellites ; polymorphisms ; distance ; alleles ; Croatia

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